TDP-43 in ALS: Stay on Target ... Almost There

被引：8
|
作者：
Jovicic, Ana [1 ]
Gitler, Aaron D. [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
来源：
NEURON | 2014年 / 81卷 / 03期
关键词：
AMYOTROPHIC-LATERAL-SCLEROSIS; RNA; GRANULES;
D O I：
10.1016/j.neuron.2014.01.034
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
ALS is associated with RNA processing impairments involving the RNA-binding protein TDP-43. Pioneering a novel RNA beacon to illuminate RNA trafficking in neurons, Alami et al. (2014) discover a cytoplasmic function for TDP-43, suggesting a new disease mechanism.
引用
收藏
页码：463 / 465
页数：3
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