TDP-43 in ALS: Stay on Target ... Almost There

被引：8

作者：

Jovicic, Ana ^{[1
]}

Gitler, Aaron D. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

来源：

NEURON | 2014年 / 81卷 / 03期

关键词：

AMYOTROPHIC-LATERAL-SCLEROSIS; RNA; GRANULES;

D O I：

10.1016/j.neuron.2014.01.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ALS is associated with RNA processing impairments involving the RNA-binding protein TDP-43. Pioneering a novel RNA beacon to illuminate RNA trafficking in neurons, Alami et al. (2014) discover a cytoplasmic function for TDP-43, suggesting a new disease mechanism.

引用

页码：463 / 465

页数：3

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