Improved sensitivity of a graphene FET biosensor using porphyrin linkers

被引：15

作者：

Kawata, Takuya ^{[1
]}

Ono, Takao ^{[1
]}

Kanai, Yasushi ^{[1
]}

Ohno, Yasuhide ^{[1
,2
]}

Maehashi, Kenzo ^{[1
,3
]}

Inoue, Koichi ^{[1
]}

Matsumoto, Kazuhiko ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan

[2] Tokushima Univ, Grad Sch Sci & Technol, Tokushima 7708506, Japan

[3] Tokyo Univ Agr & Technol, Inst Engn, Koganei, Tokyo 1848588, Japan

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS | 2018年 / 57卷 / 06期

基金：

日本科学技术振兴机构;

关键词：

WALLED CARBON NANOTUBES; FIELD-EFFECT TRANSISTOR; LABEL-FREE; NONCOVALENT FUNCTIONALIZATION; PROTEIN;

D O I：

10.7567/JJAP.57.065103

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Graphene FET (G-FET) biosensors have considerable potential due to the superior characteristics of graphene. Realizing this potential requires judicious choice of the linker molecule connecting the target-specific receptor molecule to the graphene surface, yet there are few reports comparing linker molecules for G-FET biosensors. In this study, tetrakis(4-carboxyphenyl) porphyrin (TCPP) was used as a linker for surface modification of a G-FET and the properties of the device were compared to those of a G-FET device modified with the conventional linker 1-pyrenebutanoic acid succinimidyl ester (PBASE). TCPP modification resulted in a higher density of receptor immunoglobulin E (IgE) aptamer molecules on the G-FET. The detection limit of the target IgE was enhanced from 13nM for the PBASE-modified G-FET to 2.2nM for the TCPP-modified G-FET, suggesting that the TCPP linker is a powerful candidate for G-FET modification. (C) 2018 The Japan Society of Applied Physics

引用

页数：4

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