Microevolution of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Humans, Egypt, 2007-2011

被引：30

作者：

Younan, Mary ^{[1
,2
]}

Poh, Mee Kian ^{[3
]}

Elassal, Emad ^{[2
]}

Davis, Todd ^{[3
]}

Rivailler, Pierre ^{[3
]}

Balish, Amanda L. ^{[3
]}

Simpson, Natosha ^{[3
]}

Jones, Joyce ^{[3
]}

Deyde, Varough ^{[3
]}

Loughlin, Rosette ^{[3
]}

Perry, Ije ^{[3
]}

Gubareva, Larisa ^{[3
]}

ElBadry, Maha A. ^{[2
]}

Truelove, Shaun ^{[2
]}

Gaynor, Anne M. ^{[2
]}

Mohareb, Emad ^{[2
]}

Amin, Magdy ^{[4
]}

Cornelius, Claire ^{[2
]}

Pimentel, Guillermo ^{[2
]}

Earhart, Kenneth ^{[2
]}

Naguib, Amel ^{[5
]}

Abdelghani, Ahmed S. ^{[5
]}

Refaey, Samir ^{[5
]}

Klimov, Alexander I. ^{[3
]}

Donis, Ruben O. ^{[3
]}

Kandeel, Amr ^{[5
]}

机构：

[1] US Naval Med Res Unit 3, Viral & Zoonot Dis Res Program, Cairo, Egypt

[2] US Naval Med Res Unit 3, Cairo, Egypt

[3] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

[4] Cairo Univ, Cairo, Egypt

[5] Minist Hlth & Populat, Cairo, Egypt

来源：

EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 01期

关键词：

GENETIC DIVERSITY; HONG-KONG; H5N1; BINDING; PROTEIN;

D O I：

10.3201/eid1901.121080

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyzed highly pathogenic avian influenza A(H5N1) viruses isolated from humans infected in Egypt during 2007-2011. All analyzed viruses evolved from the lineage of subtype H5N1 viruses introduced into Egypt in 2006; we found minimal evidence of reassortment and no exotic introductions. The hemagglutinin genes of the viruses from 2011 formed a monophyletic group within clade 2.2.1 that also included human viruses from 2009 and 2010 and contemporary viruses from poultry; this finding is consistent with zoonotic transmission. Although molecular markers suggestive of decreased susceptibility to antiviral drugs were detected sporadically in the neuraminidase and matrix 2 proteins, functional neuraminidase inhibition assays did not identify resistant viruses. No other mutations suggesting a change in the threat to public health were detected in the viral proteomes. However, a comparison of representative subtype H5N1 viruses from 2011 with older subtype H5N1 viruses from Egypt revealed substantial antigenic drift.

引用

页码：43 / 50

页数：8

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