Encoding of Rules by Neurons in the Human Dorsolateral Prefrontal Cortex

被引：32

作者：

Mian, Matthew K. ^{[1
]}

Sheth, Sameer A. ^{[1
]}

Patel, Shaun R. ^{[1
,2
]}

Spiliopoulos, Konstantinos ^{[1
]}

Eskandar, Emad N. ^{[1
]}

Williams, Ziv M. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Nayef al Rodhan Labs,Dept Neurosurg, Boston, MA 02114 USA

[2] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA

来源：

CEREBRAL CORTEX | 2014年 / 24卷 / 03期

基金：

美国国家卫生研究院;

关键词：

abstract rules; deep brain stimulation; human neurophysiology; prefrontal cortex; ANTERIOR CINGULATE CORTEX; SHORT-TERM-MEMORY; BEHAVIORAL-CONTROL; TEMPORAL CORTEX; SINGLE NEURONS; WORKING-MEMORY; FRONTAL-CORTEX; ABSTRACT RULES; BRAIN IMAGES; TASK;

D O I：

10.1093/cercor/bhs361

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We use rules to extend learned behavior beyond specific instances to general scenarios. The prefrontal cortex (PFC) is thought to play an important role in representing rules, as evidenced by subjects who have difficulty in following rules after PFC damage and by animal studies demonstrating rule sensitivity of individual PFC neurons. How rules are instantiated at the single-neuronal level in the human brain, however, remains unclear. Here, we recorded from individual neurons in the human dorsolateral prefrontal cortex (DLPFC) as subjects performed a task in which they evaluated pairs of images using either of 2 abstract rules. We find that DLPFC neurons selectively encoded these rules while carrying little information about the subjects responses or the sensory cues used to guide their decisions.

引用

页码：807 / 816

页数：10

共 56 条

[31] PARALLEL NEURONAL MECHANISMS FOR SHORT-TERM-MEMORY [J].