Preliminary Findings Supporting Insula Metabolic Activity as a Predictor of Outcome to Psychotherapy and Medication Treatments for Depression

被引:29
作者
Dunlop, Boadie W. [1 ]
Kelley, Mary E. [2 ]
McGrath, Callie L. [1 ]
Craighead, W. Edward [1 ,3 ]
Mayberg, Helen S. [1 ]
机构
[1] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA USA
[3] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1176/appi.neuropsych.14030048
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A putative right anterior insula metabolism biomarker predictive of treatment outcomes was retrospectively applied to 30 depressed psychotherapy- or escitalopram-treated nonremitters who entered combination treatment. Patients whose added treatment matched the biomarker-indicated treatment remitted more often than biomarker-mismatched patients.
引用
收藏
页码:237 / 239
页数:3
相关论文
共 9 条
[1]   Neural Correlates of Rapid Antidepressant Response to Ketamine in Treatment-Resistant Unipolar Depression: A Preliminary Positron Emission Tomography Study [J].
Carlson, Paul J. ;
Diazgranados, Nancy ;
Nugent, Allison C. ;
Ibrahim, Lobna ;
Luckenbaugh, David A. ;
Brutsche, Nancy ;
Herscovitch, Peter ;
Manji, Husseini K. ;
Zarate, Carlos A., Jr. ;
Drevets, Wayne C. .
BIOLOGICAL PSYCHIATRY, 2013, 73 (12) :1213-1221
[2]   Pretreatment cerebral metabolic activity correlates with antidepressant efficacy of vagus nerve stimulation in treatment-resistant major depression: A potential marker for response? [J].
Conway, Charles R. ;
Chibnall, John T. ;
Gangwani, Sunil ;
Mintun, Mark A. ;
Price, Joseph L. ;
Hershey, Tamara ;
Giuffra, Luis A. ;
Bucholz, Richard D. ;
Christensen, Jon J. ;
Sheline, Yvette I. .
JOURNAL OF AFFECTIVE DISORDERS, 2012, 139 (03) :283-290
[3]   Neural systems supporting interoceptive awareness [J].
Critchley, HD ;
Wiens, S ;
Rotshtein, P ;
Öhman, A ;
Dolan, RJ .
NATURE NEUROSCIENCE, 2004, 7 (02) :189-195
[4]   Depression beliefs, treatment preference, and outcomes in a randomized trial for major depressive disorder [J].
Dunlop, Boadie W. ;
Kelley, Mary E. ;
Mletzko, Tanja C. ;
Velasquez, Cristina M. ;
Craighead, W. Edward ;
Mayberg, Helen S. .
JOURNAL OF PSYCHIATRIC RESEARCH, 2012, 46 (03) :375-381
[5]  
First M. B., 2016, SCID 5 CV STRUCTURED
[6]  
Haase L, SOC COGN AFFECT NEUR
[7]   A RATING SCALE FOR DEPRESSION [J].
HAMILTON, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62
[8]   Pretreatment Brain States Identify Likely Nonresponse to Standard Treatments for Depression [J].
McGrath, Callie L. ;
Kelley, Mary E. ;
Dunlop, Boadie W. ;
Holtzheimer, Paul E., III ;
Craighead, W. Edward ;
Mayberg, Helen S. .
BIOLOGICAL PSYCHIATRY, 2014, 76 (07) :527-535
[9]   Toward a Neuroimaging Treatment Selection Biomarker for Major Depressive Disorder [J].
McGrath, Callie L. ;
Kelley, Mary E. ;
Holtzheimer, Paul E., III ;
Dunlop, Boadie W. ;
Craighead, W. Edward ;
Franco, Alexandre R. ;
Craddock, Cameron ;
Mayberg, Helen S. .
JAMA PSYCHIATRY, 2013, 70 (08) :821-829