An Approach to 2,4-Substituted Pyrazolo[1,5-a]pyridines and Pyrazolo[1,5-a]azepines by Ring-Closing Metathesis

被引：13

作者：

Fustero, Santos ^{[1
,2
]}

Roman, Raquel ^{[1
]}

Asensio, Amparo ^{[1
]}

Maestro, Miguel A. ^{[3
]}

Acena, Jose L. ^{[4
]}

Simon-Fuentes, Antonio ^{[1
]}

机构：

[1] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain

[2] Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain

[3] Univ A Coruna, Dept Quim Fundamental, La Coruna 15071, Spain

[4] Univ Basque Country, Dept Organ Chem 1, San Sebastian 20018, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 31期

关键词：

Synthetic methods; Asymmetric synthesis; Metathesis; Peptidomimetics; Nitrogen heterocycles; TERT-BUTANESULFINYL IMINES; FUSED BICYCLIC IMIDAZOLES; ASYMMETRIC-SYNTHESIS; ORGANOMETALLIC REAGENTS; MEDIATED ALLYLATION; RECEPTOR; DERIVATIVES; DISCOVERY; AMINES; ANTIHERPETICS;

D O I：

10.1002/ejoc.201300901

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ring-closing metathesis (RCM) reactions of dienylpyrazoles have been employed in the synthesis of pyrazolo[1,5-a]pyridine and pyrazolo[1,5-a]azepine derivatives. Based on this approach, the diastereoselective synthesis of potential peptidomimetics containing four amino acid residues with the second (i+1) and third (i+2) fragments having been substituted by bicyclic frameworks is described.

引用

页码：7164 / 7174

页数：11

共 55 条

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