Silver-catalyzed cascade radical cyclization of 2-(allyloxy)arylaldehydes with cyclopropanols: access to chroman-4-one derivatives

被引：44

作者：

Sheng, Jie ^{[1
]}

Liu, Jidan ^{[1
,2
]}

Chen, Liuqing ^{[1
]}

Zhang, Lingling ^{[1
]}

Zheng, Liyao ^{[1
]}

Wei, Xingchuan ^{[1
]}

机构：

[1] Guangzhou Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China

[2] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 09期

关键词：

C BOND-CLEAVAGE; CHROMONE DERIVATIVES; GENERAL-APPROACH; ALKOXY RADICALS; H ACTIVATION; KETONES; TRIFLUOROMETHYLATION; CYCLOALKANOLS; ANNULATION; STRATEGY;

D O I：

10.1039/c9qo00292h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel silver-catalyzed cascade radical cyclization of 2-(allyloxy) arylaldehydes with cyclopropanols was developed to synthesize carbonyl-containing alkyl-substituted chroman-4-one derivatives. This transformation is easy to conduct under mild oxidative conditions to generate two carbon-carbon bonds in a cascade radical sequence with a broad substrate scope.

引用

页码：1471 / 1475

页数：5

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