Dual Catalysis for the Redox Annulation of Nitroalkynes with Indoles: Enantioselective Construction of Indolin-3-ones Bearing Quaternary Stereocenters

被引：117

作者：

Liu, Ren-Rong ^{[1
]}

Ye, Shi-Chun ^{[1
]}

Lu, Chuan-Jun ^{[1
]}

Zhuang, Gui-Lin ^{[1
]}

Gao, Jian-Rong ^{[1
]}

Jia, Yi-Xia ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 38期

关键词：

asymmetric catalysis; carbenoids; chiral phosphoric acids; gold; indolinones; FRIEDEL-CRAFTS ALKYLATION; H INSERTION REACTION; OXO GOLD CARBENES; N-O BOND; RELAY CATALYSIS; 3-COMPONENT REACTIONS; CYCLIZATION; ISATOGENS; METAL; FUNCTIONALIZATION;

D O I：

10.1002/anie.201504697

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective redox annulation of nitro-alkynes with indoles is enabled by gold/chiral phosphoric acid dual catalysis. A range of indolin-3-one derivatives bearing quaternary stereocenters at the C2 position were afforded in good yields and excellent enantioselectivities (up to 96% ee) from readily available starting materials.

引用

页码：11205 / 11208

页数：4

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