Altered vaccine-induced immunity in children with Dravet syndrome

被引：15

作者：

Auvin, Stephane ^{[1
,2
]}

Jeljeli, Mohamed ^{[3
]}

Desnous, Beatrice ^{[1
,2
]}

Soussi-Yanicostas, Nadia ^{[1
]}

Dournaud, Pascal ^{[1
]}

Sterkers, Ghislaine ^{[3
]}

机构：

[1] Paris Diderot Univ, Sorbonne Paris Cite, INSERM, PROTECT, Paris, France

[2] Robert Debre Univ Hosp, AP HP, Pediat Neurol Dept, Paris, France

[3] Robert Debre Univ Hosp, AP HP, Dept Clin Immunol, Paris, France

来源：

EPILEPSIA | 2018年 / 59卷 / 04期

关键词：

cytokines; Dravet syndrome; epilepsy; inflammation; monocytes; SEIZURES; EPILEPSY;

D O I：

10.1111/epi.14038

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dravet syndrome (DS) is a refractory epileptic syndrome. Vaccination is the trigger of the first seizure in about 50% of cases. Fever remains a trigger of seizures during the course of the disease. We compared ex vivo cytokine responses to a combined aluminium-adjuvanted vaccine of children with DS to sex- and age-matched heathy children. Using ex vivo cytokine responses of peripheral-blood mononuclear cells and monocytes, we found that vaccine responsiveness is biased toward a proinflammatory profile in DS with a M1 phenotype of monocytes. We provide new insight into immune mechanisms associated with DS that might guide research for the development of new immunotherapeutic agents in this epilepsy syndrome.

引用

页码：E45 / E50

页数：6

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