Duchenne muscular dystrophy and epilepsy

被引：52

作者：

Pane, M. ^{[1
]}

Messina, S. ^{[2
]}

Bruno, C. ^{[3
]}

D'Amico, A. ^{[4
]}

Villanova, M. ^{[5
]}

Brancalion, B. ^{[5
]}

Sivo, S. ^{[1
]}

Bianco, F. ^{[1
]}

Striano, P. ^{[3
]}

Battaglia, D. ^{[1
]}

Letiori, D. ^{[1
]}

Vita, G. L. ^{[2
]}

Bertini, E. ^{[4
]}

Gualandi, F. ^{[6
]}

Ricotti, V. ^{[7
]}

Ferlini, A. ^{[6
]}

Mercuri, E. ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Pediat Neurol, I-00168 Rome, Italy

[2] Univ Messina, Dept Neurosci Psychiat & Anesthesiol, I-98100 Messina, Italy

[3] G Gaslini Inst Children, Neuromuscular Dis Unit, Genoa, Italy

[4] Bambino Gesu Pediat Hosp, Dept Lab Med, Mol Med Unit, Rome, Italy

[5] Nigrisoli Hosp, Neuromuscular Rehabil Unit, Bologna, Italy

[6] Univ Ferrara, Dept Expt & Diagnost Med, Med Genet Sect, I-44100 Ferrara, Italy

[7] UCL, Inst Child Hlth, Dubowitz Neuromuscular Ctr, London, England

来源：

NEUROMUSCULAR DISORDERS | 2013年 / 23卷 / 04期

关键词：

Duchenne muscular dystrophy; Epilepsy;

D O I：

10.1016/j.nmd.2013.01.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cognitive and behavioral difficulties occur in approximately a third of patients with Duchenne muscular dystrophy. The aim of our study was to assess the prevalence of epilepsy in a cohort of 222 DMD patients. Epileptic seizures were found in 14 of the 222 DMD patients (6.3%). The age of onset ranged from 3 months to 16 years (mean 7.8). Seizures were more often focal epilepsy (n = 6), generalized tonic-clonic seizures (n = 4) or absences (n = 4). They were present in 12 of the 149 boys with normal IQ (8.1%) and in two of the 73 with mental retardation (2.7%). In two cases the parents did not report any past or present history of seizures but only 'staring episodes' interpreted as a sign of 'poor attention'. In both patients EEG showed the typical pattern observed in childhood absence epilepsy. Our results suggest that the prevalence of epilepsy in our study (6.3%) is higher than in the general pediatric population (0.5-1%). The risk of epilepsy does not appear to increase in patients with mental retardation. (c) 2013 Published by Elsevier B.V.

引用

页码：313 / 315

页数：3

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