Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi

被引：33
作者：
Dong, Liao-Bin [1 ,2 ]
Wu, Xing-De [1 ]
Shi, Xin [1 ]
Zhang, Zhi-Jun [1 ]
Yang, Jing [1 ]
Zhao, Qin-Shi [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Scripps Res Inst, Dept Chem, Jupiter, FL 33458 USA
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 18期
关键词：
ELECTRONIC CIRCULAR-DICHROISM; HUPERZINE-A; CONFORMATIONAL-ANALYSIS; PALHINHAEA-CERNUA; NMR PARAMETERS; CASUARINOIDES; PREDICTION; CHEMISTRY; SKELETON;
D O I：
10.1021/acs.orglett.6b02065
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Five new Lycopodium alkaloids, phleghenrines A-D (1-4) and neophleghenrine A (5), were isolated from Phlegmariurus henryi (Baker) Ching. The structures and absolute configurations of 1-5 were determined using extensive spectroscopic data coupled with computational calculations and revealed 1-4 possess a bicyclo [3.2.2]-nonane core, whereas 5 possesses an unprecedented 9-azaprotoadamantane core. Compounds 1 and 4 showed potent acetyl-cholinesterase (AChE) inhibitory activities, and 4 is a good lead natural product for the treatment of Alzheimer's disease.
引用
收藏
页码：4498 / 4501
页数：4
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