Platinum wire implants coated with PEDOT/carbon nanotube conducting polymer films in the brain of rats: A histological evaluation

被引：9

作者：

Cheng Xuan ^{[1
]}

Li Chengyan ^{[1
]}

Rao Li ^{[1
]}

Zhou Haihan ^{[2
]}

Li Tao ^{[1
]}

Duan Yanwen ^{[2
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Neurol, Wuhan 430060, Peoples R China

[2] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

来源：

JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION | 2012年 / 27卷 / 06期

基金：

中国国家自然科学基金;

关键词：

neural electrodes; biocompatibility; poly; (3; 4-ethylenedioxythiophene) (PEDOT); carbon nanotube (CNT); laminin; neuronal nuclei; INVASIVE CORTICAL STIMULATION; TISSUE; SCAFFOLDS; NETWORKS; STROKE;

D O I：

10.1007/s11595-012-0599-8

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Platinum (Pt) implants coated with poly (3, 4-ethylenedioxythiophene)/carbon nanotube (PEDOT/CNT) composite films were implanted into the brain of rats, and the brain response was evaluated 6 weeks after the implantation. The surface morphology of Pt implants with and without the PEDOT/CNT coating was studied using scanning electron microscopy (SEM). After 6 weeks post-implantation, the expression of laminin (vascular endothelial marker) and neuronal nuclei (NeuN, neuronal marker) were evaluated by immnohistochemistry. It is revealed that the obvious improvements of the surface density of blood vessels and neurons aound the Pt implants with the coating, which were evidenced by laminin and NeuN staining in the zone within the distance of 150 mu m to the implant interface. These results suggest the PEDOT/CNT composite films can improve the biocompatibility of the Pt electrodes while it is implanted in brain.

引用

页码：1053 / 1057

页数：5

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