Arylation of Rhodium(II) Azavinyl Carbenes with Boronic Acids

被引：151

作者：

Selander, Nicklas ^{[1
]}

Worrell, Brady T. ^{[1
]}

Chuprakov, Stepan ^{[1
]}

Velaparthi, Subash ^{[1
]}

Fokin, Valery V. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 36期

基金：

美国国家科学基金会; 瑞典研究理事会; 美国国家卫生研究院;

关键词：

ALPHA-DIAZOCARBONYL COMPOUNDS; CROSS-COUPLING REACTIONS; C-H INSERTION; CATALYZED TRANSANNULATION; EFFICIENT SYNTHESIS; ARYLBORONIC ACIDS; ARYL HALIDES; TOSYLHYDRAZONES; ALKYNES; INDOLES;

D O I：

10.1021/ja3062453

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and stereoselective arylation of in situ-generated azavinyl carbenes affording enamines at ambient temperatures has been developed. These transition-metal carbenes are directly produced from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of a rhodium carboxylate catalyst. In several cases, the enamines generated in this reaction can be cyclized into substituted indoles employing copper catalysis.

引用

页码：14670 / 14673

页数：4

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