I2O5-Mediated 1,5-Cyclization of Aryldiynes with H2O: A Way To Access 3-Acyl-1-indenone Derivatives

被引：10

作者：

Zhou, Bingwei ^{[1
]}

Yang, Huan ^{[1
]}

Jin, Hongwei ^{[1
]}

Liu, Yunkui ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 04期

关键词：

PALLADIUM-CATALYZED ANNULATION; MEOTF-INDUCED CARBOANNULATION; EFFICIENT SYNTHESIS; C-H; INTRAMOLECULAR CYCLIZATION; RADICAL CYCLIZATION; BOND-CLEAVAGE; INDENONES; ALKYNES; ENEDIYNES;

D O I：

10.1021/acs.joc.8b03151

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile I2O5-mediated 1,5-cyclization of aryldiynes with H2O has been successfully developed, leading to a broad range of substituted 3-acyl-1-indenones in moderate to excellent yields. The protocol has advantages of a metal-free process, mild reaction conditions, simple operation, and broad functional group tolerance. In the reaction, H2O is used as both a cosolvent and an oxygen source.

引用

收藏

页码：2169 / 2177

页数：9

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