Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials

被引：127
作者：
Vetvicka, Vaclav [1 ]
Vannucci, Luca [2 ]
Sima, Petr [2 ]
Richter, Josef [3 ]
机构：
[1] Univ Louisville, Dept Pathol & Lab Med, Louisville, KY 40292 USA
[2] Inst Microbiol, Dept Immunol, Prague 14220, Czech Republic
[3] Zdravotni Ustav Sidlem Usti Nad Labem, Usti Nad Labem 40001, Czech Republic
来源：
MOLECULES | 2019年 / 24卷 / 07期
关键词：
glucan; drug; immunity; food; supplement; infection; mushrooms; PLEUROTUS-OSTREATUS; INNATE IMMUNITY; RESPIRATORY-INFECTIONS; OAT-BRAN; RESISTANCE; RESPONSES; MICE; NUTRITION; CYTOKINES; ANTITUMOR;
D O I：
10.3390/molecules24071251
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glucans are part of a group of biologically active natural molecules and are steadily gaining strong attention not only as an important food supplement, but also as an immunostimulant and potential drug. This paper represents an up-to-date review of glucans (beta-1,3-glucans) and their role in various immune reactions and the treatment of cancer. With more than 80 clinical trials evaluating their biological effects, the question is not if glucans will move from food supplement to widely accepted drug, but how soon.
引用
收藏
页数：17
相关论文
共 125 条
[1]   β-Glucans and their Applications in Cancer Therapy: Focus on human studies [J].
Aleem, Eiman .
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2013, 13 (05) :709-719
[2]   β-Glucan-Activated Human B Lymphocytes Participate in Innate Immune Responses by Releasing Proinflammatory Cytokines and Stimulating Neutrophil Chemotaxis [J].
Ali, Mohamed F. ;
Driscoll, Christopher B. ;
Walters, Paula R. ;
Limper, Andrew H. ;
Carmona, Eva M. .
JOURNAL OF IMMUNOLOGY, 2015, 195 (11) :5318-5326
[3]   EFFECT OF GLUCAN ON LEISHMANIA-MAJOR INFECTION IN BALB/C MICE [J].
ALTUWAIJRI, AS ;
MAHMOUD, AA ;
ALMOFLEH, IA ;
ALKHUWAITIR, SA .
JOURNAL OF MEDICAL MICROBIOLOGY, 1987, 23 (04) :363-365
[4]   HYPOCHOLESTEROLEMIC EFFECTS OF OAT AND BEAN PRODUCTS [J].
ANDERSON, JW ;
GUSTAFSON, NJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1988, 48 (03) :749-753
[5]   HYPOCHOLESTEROLEMIC EFFECTS OF OAT-BRAN OR BEAN INTAKE FOR HYPERCHOLESTEROLEMIC MEN [J].
ANDERSON, JW ;
STORY, L ;
SIELING, B ;
CHEN, WJL ;
PETRO, MS ;
STORY, J .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1984, 40 (06) :1146-1155
[6]  
[Anonymous], BIOL CHEM BETA GLUCA
[7]   Foliar application of β-D-glucan nanoparticles to control rhizome rot disease of turmeric [J].
Anusuya, Sathiyanarayanan ;
Sathiyabama, Muthukrishnan .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 72 :1205-1212
[8]   Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation [J].
Aouadi, Myriam ;
Tesz, Gregory J. ;
Nicoloro, Sarah M. ;
Wang, Mengxi ;
Chouinard, My ;
Soto, Ernesto ;
Ostroff, Gary R. ;
Czech, Michael P. .
NATURE, 2009, 458 (7242) :1180-U116
[9]  
BACON JSD, 1968, BIOCHEM J, V110, pP34
[10]   Clinical and Physiological Perspectives of -Glucans: The Past, Present, and Future [J].
Bashir, Khawaja Muhammad Imran ;
Choi, Jae-Suk .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (09)
12345678910