Microstructure and chemistry affects apatite nucleation on calcium phosphate bone graft substitutes

被引：18

作者：

Campion, Charlie R. ^{[1
,2
]}

Ball, Sara L. ^{[2
]}

Clarke, Daniel L. ^{[2
]}

Hing, Karin A. ^{[1
]}

机构：

[1] Univ London, Dept Mat, Sch Engn & Mat, London E1 4NS, England

[2] Apatech Ltd, Elstree WD6 3JT, Herts, England

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2013年 / 24卷 / 03期

关键词：

IN-VITRO BIOACTIVITY; SELF-SETTING PROPERTIES; OSTEOBLAST-LIKE CELLS; SIMULATED BODY-FLUID; GEL-DERIVED SIO2; MECHANICAL-PROPERTIES; FORMING ABILITY; HYDROXYAPATITE COATINGS; OCTACALCIUM PHOSPHATE; GLASS;

D O I：

10.1007/s10856-012-4833-x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The bioactivity of calcium phosphate bone grafts of varying chemistry and strut-porosity was compared by determining the rate of formation of hydroxycarbonate apatite crystals on the material surface after being soaked in simulated body fluid for up to 30 days. Three groups of silicate-substituted hydroxyapatite material were tested, with each group comprising a different quantity of strut-porosity (23, 32, and 46 % volume). A commercially available porous beta-tricalcium phosphate bone graft substitute was tested for comparison. Results indicate that strut-porosity of a material affects the potential for formation of a precursor to bone-like apatite and further confirms previous findings that beta-tricalcium phosphate is less bioactive than hydroxyapatite.

引用

页码：597 / 610

页数：14

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