Pre-erythrocytic malaria vaccines: towards greater efficacy

被引：117

作者：

Hill, AVS

机构：

[1] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7BN, England

[2] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nri1746

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complex life cycle of the malaria parasite Plasmodium falciparum provides many options for vaccine design. Several new types of vaccine are now being evaluated in clinical trials. Recently, two vaccine candidates that target the pre-erythrocytic stages of the malaria life cycle - a protein particle vaccine with a powerful adjuvant and a prime - boost viral-vector vaccine - have entered Phase II clinical trials in the field and the first has shown partial efficacy in preventing malarial disease in African children. This Review focuses on the potential immunological basis for the encouraging partial protection induced by these vaccines, and it considers ways for developing more effective malaria vaccines.

引用

页码：21 / 32

页数：12

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