Future therapies for food allergy

被引：2

作者：

McWilliams, Laurie M. ^{[2
]}

Mousallem, Talal ^{[2
]}

Burks, A. Wesley ^{[1
]}

机构：

[1] Univ N Carolina, Dept Pediat, Chapel Hill, NC 27515 USA

[2] Duke Univ, Dept Pediat, Durham, NC 27706 USA

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2012年 / 8卷 / 10期

基金：

美国国家卫生研究院;

关键词：

food allergy; oral immunotherapy; sublingual immunotherapy; subcutaneous immunotherapy; anaphylaxis; desensitization; tolerance; EGG ORAL IMMUNOTHERAPY; BIRCH-POLLEN; DOUBLE-BLIND; SUBLINGUAL IMMUNOTHERAPY; ANAPHYLACTIC REACTIONS; MURINE MODEL; CONTROLLED-TRIAL; PEANUT ALLERGY; APPLE; TOLERANCE;

D O I：

10.4161/hv.20868

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Food allergy affects 3.9% of US children and is increasing in prevalence. The current standard of care involves avoidance of the triggering food and treatment for accidental ingestions. While there is no current curative treatment, there are a number of therapeutic strategies under investigation. Allergen specific therapies include oral and sublingual immunotherapy with native food protein as well as recombinant food proteins. Allergen non-specific therapies include a Chinese herbal formula (FAHF-2) and the use of anti-IgE monoclonal antibody therapy. Although none of these treatments are ready for clinical use, these therapeutic strategies present promising options for the future of food allergy.

引用

页码：1479 / 1484

页数：6

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