Whole Exome Sequencing in the Accurate Diagnosis of Bilateral Breast Cancer: a Case Study

被引：7
作者：
Li, Xiaoling [1 ,2 ]
Yang, Mei [2 ]
Zhang, Qiangzu [3 ]
Fan, Yanhui [3 ]
Zhu, Teng [2 ]
Chen, Fulong [2 ]
Wang, Kun [1 ,2 ]
机构：
[1] Southern Med Univ, Sch Clin Med 2, Guangzhou, Guangdong, Peoples R China
[2] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Canc Ctr, Dept Breast Canc, 123 Huifu West Rd, Guangzhou 510080, Guangdong, Peoples R China
[3] Phil Rivers Technol, Beijing, Peoples R China
来源：
JOURNAL OF BREAST CANCER | 2019年 / 22卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Breast neoplasms; Differential diagnosis; Neoplasm metastasis; Whole exome sequencing; METASTASIS;
D O I：
10.4048/jbc.2019.22.e10
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
When faced with a case of bilateral breast cancer (BBC), understanding how to differentiate bilateral primary breast cancer from contralateral metastatic breast cancer is essential for treatment, but clear identification criteria have not been established to date. Diverse events play different roles in the therapy and prognosis of BBC; hence, it is of great significance to detect a more comprehensive and convincing technique to make an accurate differential diagnosis. We report a rare case of synchronous BBC in a 61-year-old Chinese woman. Based on her clinical and pathological features and the use of whole exome sequencing and cancer genome analysis, we concluded that the patient developed contralateral metastatic breast cancer which metastasized from left to right. Therefore, together with clinical, pathological and cancer genomics information, we could precisely define the origin and evolution of BBC.
引用
收藏
页码：131 / 140
页数：10
相关论文
共 16 条
  • [1] The genetics and genomics of cancer
    Balmain, A
    Gray, J
    Ponder, B
    [J]. NATURE GENETICS, 2003, 33 (Suppl 3) : 238 - 244
  • [2] Pathological and molecular characteristics distinguishing contralateral metastatic from new primary breast cancer
    Banelli, B.
    Casciano, I.
    Di Vinci, A.
    Gatteschi, B.
    Levaggi, A.
    Carli, F.
    Bighin, C.
    Salvi, S.
    Allemanni, G.
    Ghiorzo, P.
    Pronzato, P.
    Venturini, M.
    Romani, M.
    Del Mastro, L.
    [J]. ANNALS OF ONCOLOGY, 2010, 21 (06) : 1237 - 1242
  • [3] Clinical course of 771 patients with bilateral breast cancer: Characteristics associated with overall and recurrence-free survival
    Beinart, Garth
    Gonzalez-Angulo, Ana M.
    Broglio, Kristine
    Mejia, Jaime
    Ruggeri, Anthony
    Mininberg, Eric
    Hortobagyi, Gabriel N.
    Valero, Vicente
    [J]. CLINICAL BREAST CANCER, 2007, 7 (11) : 867 - 874
  • [4] Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management
    Brennan, Meagan Elizabeth
    Houssami, Nehmat
    Lord, Sarah
    Macaskill, Petra
    Irwig, Les
    Dixon, J. Michael
    Warren, Ruth M. L.
    Ciatto, Stefano
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (33) : 5640 - 5649
  • [5] BILATERAL PRIMARY BREAST-CANCER - A PROSPECTIVE-STUDY OF DISEASE INCIDENCE
    CHAUDARY, MA
    MILLIS, RR
    HOSKINS, EOL
    HALDER, M
    BULBROOK, RD
    CUZICK, J
    HAYWARD, JL
    [J]. BRITISH JOURNAL OF SURGERY, 1984, 71 (09) : 711 - 714
  • [6] Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    Ding, Li
    Ley, Timothy J.
    Larson, David E.
    Miller, Christopher A.
    Koboldt, Daniel C.
    Welch, John S.
    Ritchey, Julie K.
    Young, Margaret A.
    Lamprecht, Tamara
    McLellan, Michael D.
    McMichael, Joshua F.
    Wallis, John W.
    Lu, Charles
    Shen, Dong
    Harris, Christopher C.
    Dooling, David J.
    Fulton, Robert S.
    Fulton, Lucinda L.
    Chen, Ken
    Schmidt, Heather
    Kalicki-Veizer, Joelle
    Magrini, Vincent J.
    Cook, Lisa
    McGrath, Sean D.
    Vickery, Tammi L.
    Wendl, Michael C.
    Heath, Sharon
    Watson, Mark A.
    Link, Daniel C.
    Tomasson, Michael H.
    Shannon, William D.
    Payton, Jacqueline E.
    Kulkarni, Shashikant
    Westervelt, Peter
    Walter, Matthew J.
    Graubert, Timothy A.
    Mardis, Elaine R.
    Wilson, Richard K.
    DiPersio, John F.
    [J]. NATURE, 2012, 481 (7382) : 506 - 510
  • [7] Genome remodelling in a basal-like breast cancer metastasis and xenograft
    Ding, Li
    Ellis, Matthew J.
    Li, Shunqiang
    Larson, David E.
    Chen, Ken
    Wallis, Johnw.
    Harris, Christopher C.
    McLellan, Michael D.
    Fulton, Robert S.
    Fulton, Lucinda L.
    Abbott, Rachel M.
    Hoog, Jeremy
    Dooling, David J.
    Koboldt, Daniel C.
    Schmidt, Heather
    Kalicki, Joelle
    Zhang, Qunyuan
    Chen, Lei
    Lin, Ling
    Wendl, Michael C.
    McMichael, Joshua F.
    Magrini, Vincent J.
    Cook, Lisa
    McGrath, Sean D.
    Vickery, Tammi L.
    Appelbaum, Elizabeth
    DeSchryver, Katherine
    Davies, Sherri
    Guintoli, Therese
    Lin, Li
    Crowder, Robert
    Tao, Yu
    Snider, Jacqueline E.
    Smith, Scott M.
    Dukes, Adam F.
    Sanderson, Gabriel E.
    Pohl, Craig S.
    Delehaunty, Kim D.
    Fronick, Catrina C.
    Pape, Kimberley A.
    Reed, Jerry S.
    Robinson, Jody S.
    Hodges, Jennifer S.
    Schierding, William
    Dees, Nathan D.
    Shen, Dong
    Locke, Devin P.
    Wiechert, Madeline E.
    Eldred, James M.
    Peck, Josh B.
    [J]. NATURE, 2010, 464 (7291) : 999 - 1005
  • [8] Incidence and prognosis of synchronous and Metachronous bilateral breast cancer
    Hartman, Mikael
    Czene, Kamila
    Reilly, Marie
    Adolfsson, Jan
    Bergh, Jonas
    Adami, Hans-Olov
    Dickman, Paul W.
    Hall, Per
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (27) : 4210 - 4216
  • [9] Contralateral breast cancer: molecular differentiation between metastasis and second primary cancer
    Janschek, E
    Kandioler-Eckersberger, D
    Ludwig, C
    Kappel, S
    Wolf, B
    Taucher, S
    Rudas, M
    Gnant, M
    Jakesz, R
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2001, 67 (01) : 1 - 8
  • [10] Bilateral breast cancer, synchronous and metachronous; differences and outcome
    Jobsen, J. J.
    van der Palen, J.
    Ong, F.
    Riemersma, S.
    Struikmans, H.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2015, 153 (02) : 277 - 283
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