Neonatal Diabetes Mellitus An Update on Diagnosis and Management

被引：128

作者：

Lemelman, Michelle Blanco ^{[1
]}

Letourneau, Lisa ^{[2
]}

Greeley, Siri Atma W. ^{[3
]}

机构：

[1] Sect Adult & Pediat Endocrinol Diabet & Metab, MC 5053,5841 South Maryland Ave, Chicago, IL 60637 USA

[2] Univ Chicago Med, Kovler Diabet Ctr, Monogen Diabet Registry, 900 East 57th St, Chicago, IL 60637 USA

[3] Univ Chicago, Sect Adult & Pediat Endocrinol Diabet & Metab, Kovler Diabet Ctr, 900 East 57th St, Chicago, IL 60637 USA

来源：

CLINICS IN PERINATOLOGY | 2018年 / 45卷 / 01期

关键词：

Neonatal diabetes; Monogenic diabetes; Genetic; Insulin; Glyburide; LOW-BIRTH-WEIGHT; SULFONYLUREA TREATMENT; INTERNATIONAL COHORT; ORAL SULFONYLUREAS; INS GENE; MUTATIONS; INSULIN; INFANTS; CHILDHOOD; CHILDREN;

D O I：

10.1016/j.clp.2017.10.006

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Neonatal diabetes mellitus is likely to be due to an underlying mono genic defect when it occurs at less than 6 months of age. Early recognition and urgent genetic testing are important for predicting the clinical course and raising awareness of possible additional features. Early treatment of sulfonylurea-responsive types of neonatal diabetes may improve neurologic outcomes. It is important to distinguish neonatal diabetes mellitus from other causes of hyperglycemia in newborns. Other causes include infection, stress, and inadequate pancreatic insulin production in preterm infants, among others. This article explores the diagnostic approach, mutation types, management, and clinical course of neonatal diabetes.

引用

页码：41 / +

页数：20

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