LncRNA CTBP1-AS2 regulates miR-216a/PTEN to suppress ovarian cancer cell proliferation

被引：23

作者：

Cui, Kaiying ^{[1
]}

Zhu, Genhai ^{[1
]}

机构：

[1] Hainan Peoples Hosp, Dept Gynaecol, Haikou 570311, Hainan, Peoples R China

来源：

JOURNAL OF OVARIAN RESEARCH | 2020年 / 13卷 / 01期

关键词：

CTBP1-AS2; Ovarian cancer; miR-216a; PTEN; Proliferation; EPITHELIAL-MESENCHYMAL TRANSITION; LONG NONCODING RNAS; TARGETED THERAPY; METASTASIS; DIAGNOSIS; RISK;

D O I：

10.1186/s13048-020-00689-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background We analyzed TCGA dataset and observed the downregulation of CTBP1-AS2 in ovarian cancer (OC), while the function of CTBP1-AS2 has only been investigated in diabetes and cardiomyocyte hypertrophy, but not in cancer biology. We therefore analyzed the involvement of CTBP1-AS2 in OC. Result We found that CTBP1-AS2 was downregulated in OC and predicted poor survival. CTBP1-AS2 in luciferase activity assay interacted with miR-216a, while overexpression of CTBP1-AS2 and miR-216a had no significant effects on the expression of each other. However, increased expression level of PTEN, a target of miR-216a, was observed after CTBP1-AS2 overexpression. Increased proliferation rate of OC cells was observed after the overexpression of miR-216a. CTBP1-AS2 and PTEN overexpression resulted in the reduced proliferation rate of OC cells and reduced effects of miR-216a overexpression. Conclusion CTBP1-AS2 regulates miR-216a/PTEN to suppress OC cell proliferation.

引用

页数：6

共 17 条

[1] Duration of Adulthood Overweight, Obesity, and Cancer Risk in the Women's Health Initiative: A Longitudinal Study from the United States [J].

Arnold, Melina ;

Jiang, Luohua ;

Stefanick, Marcia L. ;

Johnson, Karen C. ;

Lane, Dorothy S. ;

LeBlanc, Erin S. ;

Prentice, Ross ;

Rohan, Thomas E. ;

Snively, Beverly M. ;

Vitolins, Mara ;

Zaslavsky, Oleg ;

Soerjomataram, Isabelle ;

Anton-Culver, Hoda .

PLOS MEDICINE, 2016, 13 (08)

[2] Therapeutic Targeting of Long Non-Coding RNAs in Cancer [J].

Arun, Gayatri ;

Diermeier, Sarah D. ;

Spector, David L. .

TRENDS IN MOLECULAR MEDICINE, 2018, 24 (03) :257-277

[3] Genetic risk factors for ovarian cancer and their role for endometriosis risk [J].

Burghaus, Stefanie ;

Fasching, Peter A. ;

Haeberle, Lothar ;

Ruebner, Matthias ;

Buechner, Kathrin ;

Blum, Simon ;

Engel, Anne ;

Ekici, Arif B. ;

Hartmann, Arndt ;

Hein, Alexander ;

Beckmann, Matthias W. ;

Renner, Stefan P. .

GYNECOLOGIC ONCOLOGY, 2017, 145 (01) :142-147

[4] Long noncoding RNAs and cancer, an overview [J].

Camacho, Cristel V. ;

Choudhari, Ramesh ;

Gadad, Shrikanth S. .

STEROIDS, 2018, 133 :93-95

[5]

Doubeni CA, 2016, AM FAM PHYSICIAN, V93, P937

[6] A Systematic Review of Symptoms for the Diagnosis of Ovarian Cancer [J].

Ebell, Mark H. ;

Culp, MaryBeth B. ;

Radke, Taylor J. .

AMERICAN JOURNAL OF PREVENTIVE MEDICINE, 2016, 50 (03) :384-394

[7] Genetic and molecular changes in ovarian cancer [J].

Hollis, Robert L. ;

Gourley, Charlie .

CANCER BIOLOGY & MEDICINE, 2016, 13 (02) :236-247

[8] Cancer statistics, 2007 [J].

Jemal, Ahmedin ;

Siegel, Rebecca ;

Ward, Elizabeth ;

Murray, Taylor ;

Xu, Jiaquan ;

Thun, Michael J. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2007, 57 (01) :43-66

[9] miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14 [J].

Ji, Quanbo ;

Xu, Xiaojie ;

Li, Ling ;

Goodman, Stuart B. ;

Bi, Wenzhi ;

Xu, Meng ;

Xu, Yameng ;

Fan, Zhongyi ;

Maloney, William J. ;

Ye, Qinong ;

Wang, Yan .

CELL DEATH & DISEASE, 2017, 8 :e3103-e3103

[10] Smoking and risk of ovarian cancer by histological subtypes: an analysis among 300 000 Norwegian women [J].

Licaj, Idlir ;

Jacobsen, Bjarne Koster ;

Selmer, Randi Marie ;

Maskarinec, Gertraud ;

Weiderpass, Elisabete ;

Gram, Inger Torhild .

BRITISH JOURNAL OF CANCER, 2017, 116 (02) :270-276

← 1 2 →