LncRNA CTBP1-AS2 regulates miR-216a/PTEN to suppress ovarian cancer cell proliferation

被引：21
|
作者：
Cui, Kaiying [1 ]
Zhu, Genhai [1 ]
机构：
[1] Hainan Peoples Hosp, Dept Gynaecol, Haikou 570311, Hainan, Peoples R China
来源：
JOURNAL OF OVARIAN RESEARCH | 2020年 / 13卷 / 01期
关键词：
CTBP1-AS2; Ovarian cancer; miR-216a; PTEN; Proliferation; EPITHELIAL-MESENCHYMAL TRANSITION; LONG NONCODING RNAS; TARGETED THERAPY; METASTASIS; DIAGNOSIS; RISK;
D O I：
10.1186/s13048-020-00689-6
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background We analyzed TCGA dataset and observed the downregulation of CTBP1-AS2 in ovarian cancer (OC), while the function of CTBP1-AS2 has only been investigated in diabetes and cardiomyocyte hypertrophy, but not in cancer biology. We therefore analyzed the involvement of CTBP1-AS2 in OC. Result We found that CTBP1-AS2 was downregulated in OC and predicted poor survival. CTBP1-AS2 in luciferase activity assay interacted with miR-216a, while overexpression of CTBP1-AS2 and miR-216a had no significant effects on the expression of each other. However, increased expression level of PTEN, a target of miR-216a, was observed after CTBP1-AS2 overexpression. Increased proliferation rate of OC cells was observed after the overexpression of miR-216a. CTBP1-AS2 and PTEN overexpression resulted in the reduced proliferation rate of OC cells and reduced effects of miR-216a overexpression. Conclusion CTBP1-AS2 regulates miR-216a/PTEN to suppress OC cell proliferation.
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页数：6
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