Neural stem cells: mechanisms and modeling

被引：43
作者：
Yao, Jun [1 ]
Mu, Yangling [1 ]
Gage, Fred H. [1 ]
机构：
[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA
来源：
PROTEIN & CELL | 2012年 / 3卷 / 04期
关键词：
neural stem cell; hippocampus; olfactory bulb; induced pluripotent stem cell; neurodegenerative disease; neurodevelopmental disorder; ADULT HIPPOCAMPAL NEUROGENESIS; FAMILIAL ALZHEIMERS-DISEASE; ENDOTHELIAL GROWTH-FACTOR; GENOME-WIDE ASSOCIATION; SUBVENTRICULAR ZONE; PROGENITOR CELLS; ALPHA-SYNUCLEIN; NEURONAL DIFFERENTIATION; DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE;
D O I：
10.1007/s13238-012-2033-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the adult brain, neural stem cells have been found in two major niches: the hippocampus and the olfactory bulb. Neurons derived from these stem cells contribute to learning, memory, and the autonomous repair of the brain under pathological conditions. Hence, the physiology of adult neural stem cells has become a significant component of research on synaptic plasticity and neuronal disorders. In addition, the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the pathological and pharmacological study of neuronal disorders. In this review, we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique.
引用
收藏
页码：251 / 261
页数：11
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