共 41 条
In silico design novel dihydropyrimio[4, 5-d]pyrimidine derivatives as inhibitors for colony-stimulating factor-1 receptor based on 3D-QSAR, molecular docking and molecular dynamics simulation
被引:9
作者:

Chu, Han
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing 400054, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China

He, Qing-xiu
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing 400054, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China

Wang, Juan
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing 400054, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China

Hu, Yong
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing 400054, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China

Wang, Yuan-qiang
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing 400054, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China

Lin, Zhi-hua
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing 400054, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China
机构:
[1] Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400054, Peoples R China
[2] Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing 400054, Peoples R China
基金:
中国国家自然科学基金;
关键词:
Colony-stimulating factor-1 receptor;
Inhibitor;
dihydropyrimio[4 5-D] pyrimidine derivatives;
3D-QSAR;
Molecular docking;
Molecular dynamics simulation;
PARTICLE MESH EWALD;
FREE-ENERGIES;
MACROPHAGES;
CANCER;
CORRELATE;
BINDING;
PREDICT;
CSF-1;
AMBER;
POOR;
D O I:
10.1016/j.molstruc.2020.128617
中图分类号:
O64 [物理化学(理论化学)、化学物理学];
学科分类号:
070304 ;
081704 ;
摘要:
Colony-stimulating factor-1 receptor (CSF-1R) can affect the further development of tumors by regulating the generation and biological activity of mononuclear-phagocytic lineage cells, and is an important potential target for cancer treatment. In this study, we selected 48 dihydropyrimio [4, 5-d]pyrimidine derivatives and performed 3D-QSAR studies on them using CoMFA and CoMSIA model. The results showed that CoMFA (n = 10; q(2) = 0.626; r(2) = 0.998) and CoMSIA (n = 10; q(2) = 0.684; r(2) = 0.997) had good stability and predictability. The relationship between the activity and structure of the compounds was analyzed by counter maps of the steric, electrostatic and hydrophobic fields. Subsequently, molecular docking was used to explore key amino acids and docking modes at the active site. Based on these results, we designed 9 new dihydropyrimio [4, 5-d] pyrimidine derivatives and predicted their activities. The results indicated that these compounds had good predictive activities and ADME/T properties. MD simulation analysis confirmed that the residues Leu588 and Cys666 in the active site played a key role; at the same time, these compounds mainly bind to CSF-1R through hydrophobic interactions and hydrogen bonding. These results provided important reference for the discovery and design of new CSF-1R inhibitors. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页数:13
相关论文
共 41 条
[1]
QSAR analysis of coumarin-based benzamides as histone deacetylase inhibitors using CoMFA, CoMSIA and HQSAR methods
[J].
Abdizadeh, Rahman
;
Hadizadeh, Farzin
;
Abdizadeh, Tooba
.
JOURNAL OF MOLECULAR STRUCTURE,
2020, 1199

论文数: 引用数:
h-index:
机构:

Hadizadeh, Farzin
论文数: 0 引用数: 0
h-index: 0
机构:
Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran
Mashhad Univ Med Sci, Sch Pharm, Dept Med Chem, Mashhad, Razavi Khorasan, Iran Shahrekord Univ Med Sci, Fac Med, Dept Med Parasitol & Mycol, Shahrekord, Iran

Abdizadeh, Tooba
论文数: 0 引用数: 0
h-index: 0
机构:
Sharekord Univ Med Sci, Clin Biochem Res Ctr, Basic Hlth Sci Inst, Shahrekord, Iran Shahrekord Univ Med Sci, Fac Med, Dept Med Parasitol & Mycol, Shahrekord, Iran
[2]
Elevated CSF1 serum concentration predicts poor overall survival in women with early breast cancer
[J].
Aharinejad, Seyedhossein
;
Salama, Mohamed
;
Paulus, Patrick
;
Zins, Karin
;
Berger, Andreas
;
Singer, Christian F.
.
ENDOCRINE-RELATED CANCER,
2013, 20 (06)
:777-783

Aharinejad, Seyedhossein
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Dept Cardiac Surg, A-1090 Vienna, Austria
Med Univ Vienna, Dept Cardiovasc Res, A-1090 Vienna, Austria Med Univ Vienna, Dept Cardiac Surg, A-1090 Vienna, Austria

论文数: 引用数:
h-index:
机构:

Paulus, Patrick
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Dept Cardiovasc Res, A-1090 Vienna, Austria Med Univ Vienna, Dept Cardiac Surg, A-1090 Vienna, Austria

论文数: 引用数:
h-index:
机构:

Berger, Andreas
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Dept Obstet & Gynecol, A-1090 Vienna, Austria
Ctr Comprehens Canc, A-1090 Vienna, Austria Med Univ Vienna, Dept Cardiac Surg, A-1090 Vienna, Austria

Singer, Christian F.
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Dept Obstet & Gynecol, A-1090 Vienna, Austria
Ctr Comprehens Canc, A-1090 Vienna, Austria Med Univ Vienna, Dept Cardiac Surg, A-1090 Vienna, Austria
[3]
Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study
[J].
Butowski, Nicholas
;
Colman, Howard
;
De Groot, John F.
;
Omuro, Antonio M.
;
Nayak, Lakshmi
;
Wen, Patrick Y.
;
Cloughesy, Timothy F.
;
Marimuthu, Adhirai
;
Haidar, Sam
;
Perry, Arie
;
Huse, Jason
;
Phillips, Joanna
;
West, Brian L.
;
Nolop, Keith B.
;
Hsu, Henry H.
;
Ligon, Keith L.
;
Molinaro, Annette M.
;
Prados, Michael
.
NEURO-ONCOLOGY,
2016, 18 (04)
:557-564

Butowski, Nicholas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Colman, Howard
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

De Groot, John F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Omuro, Antonio M.
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Hosp, Dept Neurol, New York, NY USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Nayak, Lakshmi
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Brigham & Womens Canc Ctr, Ctr Neurooncol, Boston, MA USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Wen, Patrick Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Brigham & Womens Canc Ctr, Ctr Neurooncol, Boston, MA USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Cloughesy, Timothy F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Med Ctr, Los Angeles, CA 90024 USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Marimuthu, Adhirai
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon Inc, Berkeley, CA USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Haidar, Sam
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Brigham & Womens Canc Ctr, Ctr Neurooncol, Boston, MA USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Perry, Arie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Huse, Jason
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Hosp, Dept Pathol, New York, NY USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Phillips, Joanna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

West, Brian L.
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon Inc, Berkeley, CA USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Nolop, Keith B.
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon Inc, Berkeley, CA USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Hsu, Henry H.
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon Inc, Berkeley, CA USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Ligon, Keith L.
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Brigham & Womens Canc Ctr, Ctr Neurooncol, Boston, MA USA
Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Molinaro, Annette M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA

Prados, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA Univ Calif San Francisco, 505 Parnassus Ave,M-779, San Francisco, CA 94117 USA
[4]
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy
[J].
Cannarile, Michael A.
;
Weisser, Martin
;
Jacob, Wolfgang
;
Jegg, Anna-Maria
;
Ries, Carola H.
;
Ruettinger, Dominik
.
JOURNAL FOR IMMUNOTHERAPY OF CANCER,
2017, 5

Cannarile, Michael A.
论文数: 0 引用数: 0
h-index: 0
机构:
Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany

Weisser, Martin
论文数: 0 引用数: 0
h-index: 0
机构:
Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany

Jacob, Wolfgang
论文数: 0 引用数: 0
h-index: 0
机构:
Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany

Jegg, Anna-Maria
论文数: 0 引用数: 0
h-index: 0
机构:
Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany

Ries, Carola H.
论文数: 0 引用数: 0
h-index: 0
机构:
Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany

Ruettinger, Dominik
论文数: 0 引用数: 0
h-index: 0
机构:
Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany Roche Innovat Ctr Munich, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany
[5]
Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein-protein binding free energies and re-rank binding poses generated by protein-protein docking
[J].
Chen, Fu
;
Liu, Hui
;
Sun, Huiyong
;
Pan, Peichen
;
Li, Youyong
;
Li, Dan
;
Hou, Tingjun
.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS,
2016, 18 (32)
:22129-22139

Chen, Fu
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

Liu, Hui
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

Sun, Huiyong
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

Pan, Peichen
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

Li, Youyong
论文数: 0 引用数: 0
h-index: 0
机构:
Soochow Univ, Inst Funct Nano Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

Li, Dan
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

Hou, Tingjun
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
Zhejiang Univ, State Key Lab CAD&CG, Hangzhou 310058, Zhejiang, Peoples R China Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
[6]
3D-QSAR, molecular docking, and molecular dynamics simulation of a novel thieno[3,4-d]pyrimidine inhibitor targeting human immunodeficiency virus type 1 reverse transcriptase
[J].
Chu, Han
;
He, Qing-xiu
;
Wang, Jun-wei
;
Deng, Ya-ting
;
Wang, Juan
;
Hu, Yong
;
Wang, Yuan-qiang
;
Lin, Zhi-hua
.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,
2020, 38 (15)
:4567-4578

Chu, Han
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China

He, Qing-xiu
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China

Wang, Jun-wei
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China

Deng, Ya-ting
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China

Wang, Juan
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China

Hu, Yong
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China

Wang, Yuan-qiang
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China

Lin, Zhi-hua
论文数: 0 引用数: 0
h-index: 0
机构:
Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China
Key Lab Screening & Act Evaluat Targeted Drugs, Chongqing, Peoples R China
Chongqing Univ, Sch Chem & Chem Engn, Chongqing, Peoples R China Chongqing Univ Technol, Dept Pharm & Bioengn, Chongqing 400050, Peoples R China
[7]
COMPARATIVE MOLECULAR-FIELD ANALYSIS (COMFA) .1. EFFECT OF SHAPE ON BINDING OF STEROIDS TO CARRIER PROTEINS
[J].
CRAMER, RD
;
PATTERSON, DE
;
BUNCE, JD
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1988, 110 (18)
:5959-5967

CRAMER, RD
论文数: 0 引用数: 0
h-index: 0

PATTERSON, DE
论文数: 0 引用数: 0
h-index: 0

BUNCE, JD
论文数: 0 引用数: 0
h-index: 0
[8]
PARTICLE MESH EWALD - AN N.LOG(N) METHOD FOR EWALD SUMS IN LARGE SYSTEMS
[J].
DARDEN, T
;
YORK, D
;
PEDERSEN, L
.
JOURNAL OF CHEMICAL PHYSICS,
1993, 98 (12)
:10089-10092

DARDEN, T
论文数: 0 引用数: 0
h-index: 0
机构: National Institute of Environmental Health Sciences, Research Triangle Park

YORK, D
论文数: 0 引用数: 0
h-index: 0
机构: National Institute of Environmental Health Sciences, Research Triangle Park

论文数: 引用数:
h-index:
机构:
[9]
Macrophage Regulation of Tumor Responses to Anticancer Therapies
[J].
De Palma, Michele
;
Lewis, Claire E.
.
CANCER CELL,
2013, 23 (03)
:277-286

De Palma, Michele
论文数: 0 引用数: 0
h-index: 0
机构:
Swiss Fed Inst Technol Lausanne EPFL, Swiss Inst Expt Canc Res ISREC, Sch Life Sci, CH-1015 Lausanne, Switzerland Swiss Fed Inst Technol Lausanne EPFL, Swiss Inst Expt Canc Res ISREC, Sch Life Sci, CH-1015 Lausanne, Switzerland

Lewis, Claire E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med, Dept Oncol, Sheffield Canc Res Ctr, Sheffield S10 2RX, S Yorkshire, England Swiss Fed Inst Technol Lausanne EPFL, Swiss Inst Expt Canc Res ISREC, Sch Life Sci, CH-1015 Lausanne, Switzerland
[10]
Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
[J].
Elmore, Monica R. P.
;
Najafi, Allison R.
;
Koike, Maya A.
;
Dagher, Nabil N.
;
Spangenberg, Elizabeth E.
;
Rice, Rachel A.
;
Kitazawa, Masashi
;
Matusow, Bernice
;
Nguyen, Hoa
;
West, Brian L.
;
Green, Kim N.
.
NEURON,
2014, 82 (02)
:380-397

Elmore, Monica R. P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Najafi, Allison R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Koike, Maya A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Dagher, Nabil N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Spangenberg, Elizabeth E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Rice, Rachel A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Kitazawa, Masashi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Merced, Dept Mol & Cell Biol, Merced, CA 95343 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Matusow, Bernice
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon Inc, Berkeley, CA 94710 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Nguyen, Hoa
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon Inc, Berkeley, CA 94710 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

West, Brian L.
论文数: 0 引用数: 0
h-index: 0
机构:
Plexxikon Inc, Berkeley, CA 94710 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA

Green, Kim N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Dept Neurobiol & Behav, Irvine, CA 92697 USA