Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

被引:78
作者
Larque, Elvira [1 ]
Morales, Eva [2 ]
Leis, Rosaura [3 ]
Blanco-Carnero, Jose E. [4 ]
机构
[1] Univ Murcia, Dept Physiol, Biomed Res Inst Murcia IMIB Arrixaca, Murcia, Spain
[2] Univ Murcia, IMIB Arrixaca, Dept Publ Hlth Sci, CIBERESP, Murcia, Spain
[3] Univ Santiago de Compostela, Unit Invest Nutr Growth & Human Dev Galicia, Inst Hlth Res Santiago IDIS, Pediat Dept,Hosp Clin Univ Santiago,CiberObn, Santiago De Compostela, Spain
[4] Virgen de la Arrixaca Hosp, Gynecol Serv, Murcia, Spain
关键词
Vitamin D; 25-Hydroxyvitamin D Pregnancy; Preeclampsia; Preterm; Neurodevelopment; Wheezing; Asthma; 25-HYDROXYVITAMIN D LEVEL; D SUPPLEMENTATION; D DEFICIENCY; 1,25-DIHYDROXYVITAMIN-D CONCENTRATIONS; NEURODEVELOPMENTAL OUTCOMES; NEONATAL OUTCOMES; RISK-FACTOR; D-RECEPTOR; BONE MASS; IN-UTERO;
D O I
10.1159/000487370
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: To what extent does the circulating 25-hydroxyvitamin D (25[OH] D) concentration help to meet the physiological needs of humans is an ongoing subject of debate. Remaining unexposed to the sun to reduce melanoma cancer risk, current lifestyle with less out door activities, and increasing obesity rates, which in turn increases the storage of vitamin D in the adipose tissue, are presumably factors that contribute to the substantial upsurge in the prevalence of vitamin D deficiency in humans. Since evidence is lacking regarding the appropriate cut-off points to define vitamin D status during pregnancy, references used to establish the intake recommendations and vitamin D content of prenatal vitamin supplements are quite conservative. Summary: The foetus depends fully on maternal 25(OH)D supply. 25(OH)D readily crosses the placenta and it is activated into 1,25(OH)(2)D by foetal kidneys. Moreover, 1,25(OH)(2)D can also be synthesized within the placenta to regulate placental metabolism. The importance of vitamin D during pregnancy for maintaining maternal calcium homeostasis and therefore for foetal bone development is well recognized; major discussions are in progress regarding the potential maternal detrimental effects on pregnancy outcomes, foetal development, and the long-term health of children. Interventional studies have also evaluated the effect of vitamin D for reduction on pre-term birth and asthma programming. Key Messages: Clinically, by understanding the effects of vitamin D on perinatal outcomes, we could individualize antenatal counselling regarding vitamin D supplementation to ensure vitamin D repletion without increasing the risk of foetal hypercalcemia. (c) 2018 S. Karger AG, Basel
引用
收藏
页码:179 / 192
页数:14
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