Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes

被引：5

作者：

Ataei-Pirkooh, Angila ^{[1
]}

Tehrani, Mona ^{[1
]}

Keyvani, Hossein ^{[1
]}

Esghaei, Maryam ^{[1
]}

Tavakoli, Ahmad ^{[1
]}

Nikmanesh, Bahram ^{[1
]}

Farahmand, Mohammad ^{[1
]}

Ghaffari, Hadi ^{[1
]}

Monavari, Seyed Hamidreza ^{[1
]}

机构：

[1] Iran Univ Med Sci, Fac Med, Dept Virol, Tehran, Iran

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2019年 / 38卷 / 02期

关键词：

type; 1; diabetes; rotavirus; T1DM; children; autoantibodies; AUTOIMMUNITY; EPITOPES; MIMICRY;

D O I：

10.1080/15513815.2018.1547338

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background: Some studies implicate rotavirus infection as a trigger for the development of type 1 diabetes mellitus (T1DM) in children, however findings are controversial. Objectives: We investigated the link between rotavirus infection and autoantibodies against islet antigens and T1DM in children. Methods: Serum samples from 80 new-onset diabetic and 80 nondiabetic children were screened for anti-rotavirus IgG, anti-GAD65 and anti-IA-2 autoantibodies using ELISA kits. Results: Positivity percentages of anti-rotavirus IgG detection in diabetic and nondiabetic children were 51.3% and 35.0%, respectively (p=0.03). The mean anti-GAD65 and anti-IA-2 antibody titers in anti-rotavirus IgG positive samples were statistically higher than that the anti-rotavirus IgG negative samples. A positive correlation was found between anti-rotavirus IgG and anti-GAD65 antibody levels (p=0.004; r=0.22). Conclusions: Our findings support the hypothesis that rotovirus infection may induce T1DM in children.

引用

页码：103 / 111

页数：9

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