Umbilical cord blood PBDEs concentrations in relation to placental size at birth

被引：20
作者：
Zhao, Yan [1 ]
Song, Qi [2 ]
Cao, Zhijuan [1 ]
Su, Xiujuan [1 ]
Hua, Jing [1 ]
Zhang, Yunhui [2 ]
He, Xiaoxiao [3 ,4 ]
机构：
[1] Tongji Univ, Shanghai Matern & Infant Hosp 1, Sch Med, Shanghai, Peoples R China
[2] Fudan Univ, Sch Publ Hlth, Minist Educ, Key Lab Publ Hlth Safety, Shanghai, Peoples R China
[3] Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou, Peoples R China
[4] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China
来源：
CHEMOSPHERE | 2018年 / 201卷
关键词：
PBDEs; Placental size; Prenatal exposure; Fetal growth; POLYBROMINATED DIPHENYL ETHERS; RAT HIPPOCAMPAL-NEURONS; TROPHOBLASTS IN-VITRO; PRENATAL EXPOSURE; FLAME RETARDANTS; OXIDATIVE STRESS; FETAL-GROWTH; BREAST-MILK; MATERNAL EXPOSURE; BODY-SIZE;
D O I：
10.1016/j.chemosphere.2018.02.121
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Previous studies have linked prenatal polybrominated diphenyl ether (PBDE) exposure to adverse birth outcomes. Reductions in placental size might mediate those adverse effects. We examined whether umbilical cord blood PBDEs concentrations were associated with placental size at birth. A total of 121 mother-newborn pairs residing in Wenzhou were enrolled in this study. Concentrations of 19 PBDEs in umbilical cord blood were determined by gas chromatography tandem mass spectrometry (GC-MS). Placental length, breadth and surface area was measured by medical professionals after delivery. BDE-206, 207, 208, 209 and the total of 19 PBDE congeners concentrations were negatively associated with placental length, breadth and surface area. Our results suggest that prenatal PBDEs exposure may suppress placental growth, resulting in reduced placental size. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：20 / 24
页数：5
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