Core-shell nanofibers from poly(vinyl alcohol) based biopolymers using emulsion electrospinning as drug delivery system for cephalexin drug

被引:35
作者
Abdul Hameed, Meera Moydeen [1 ,2 ]
Mohamed Khan, Syed Ali Padusha [2 ]
Thamer, Badr M. [1 ]
Al-Enizi, Abdullah [1 ]
Aldalbahi, Ali [1 ]
El-Hamshary, Hany [1 ,3 ]
El-Newehy, Mohamed H. [1 ,3 ]
机构
[1] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia
[2] Bharathidasan Univ, Jamal Mohamed Coll, PG & Res Dept Chem, Tiruchirapalli, India
[3] Tanta Univ, Dept Chem, Fac Sci, Tanta, Egypt
来源
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | 2021年 / 58卷 / 02期
关键词
Emulsion electrospinning; biopolymers; drug delivery; wound healing; cephalexin; INTERMOLECULAR INTERACTIONS; CONTROLLED-RELEASE; SOLUTE RELEASE; FIBERS; STABILIZATION; MISCIBILITY; FABRICATION;
D O I
10.1080/10601325.2020.1832517
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Cephalexin loaded electrospun nanofibers with core-shell structures were prepared from poly(vinyl alcohol) (PVA) blended with various biopolymers such as chitosan (CH), carboxymethyl cellulose (CMC), carboxymethyl starch (CMS), and hydroxyproyl cellulose (HPC) in PVA:biopolymer ratio of 90:10. The electrospun nanofiber mats were cross-linked by heat treatment to avoid disintegration in water. Molecular interactions between the polymeric chains and the drug were analyzed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The morphology of nanofiber mats was studied by field emission scanning electron microscope (FE-SEM), and the core-shell structure formation through emulsion electrospinning was confirmed by transmission electron microscope (TEM) and confocal laser scanning microscope (CLSM). Thein vitrodrug release profile was studied and the mechanism was determined through kinetic models using non-linear regression methods. Drug release was gradual within the first 8 h. Furthermore, release predominantly occurred by a diffusion mechanism which makes this system suitable for wound healing treatment.
引用
收藏
页码:130 / 144
页数:15
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