Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications

被引：3968

作者：

Caravan, P ^{[1
]}

Ellison, JJ ^{[1
]}

McMurry, TJ ^{[1
]}

Lauffer, RB ^{[1
]}

机构：

[1] EPIX Med Inc, Cambridge, MA 02142 USA

来源：

CHEMICAL REVIEWS | 1999年 / 99卷 / 09期

关键词：

D O I：

10.1021/cr980440x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gadolinium(III) chelates remain to be the leading choice as contrast agents for magnetic resonance imaging (MRI) due to its structure and properties. The symmetric S-state of Gd(III) is a more comfortable environment for electron spins, thus, slower electronic relaxation rate occurs. Furthermore, Gd(III) chelates remain chelated in the human body and are excreted intact. The solution and solid state structures, relaxation theory, physicochemical properties, macromolecule conjugates, and applications of Gd(III) chelates are further explored.

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页码：2293 / 2352

页数：60

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