Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications

被引：3968
作者：
Caravan, P [1 ]
Ellison, JJ [1 ]
McMurry, TJ [1 ]
Lauffer, RB [1 ]
机构：
[1] EPIX Med Inc, Cambridge, MA 02142 USA
来源：
CHEMICAL REVIEWS | 1999年 / 99卷 / 09期
关键词：
D O I：
10.1021/cr980440x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Gadolinium(III) chelates remain to be the leading choice as contrast agents for magnetic resonance imaging (MRI) due to its structure and properties. The symmetric S-state of Gd(III) is a more comfortable environment for electron spins, thus, slower electronic relaxation rate occurs. Furthermore, Gd(III) chelates remain chelated in the human body and are excreted intact. The solution and solid state structures, relaxation theory, physicochemical properties, macromolecule conjugates, and applications of Gd(III) chelates are further explored.
引用
收藏
页码：2293 / 2352
页数：60
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共 345 条
[1]   Nuclear magnetic resonance-paramagnetic relaxation enhancements: Influence of spatial quantization of the electron spin when the zero-field splitting energy is larger than the Zeeman energy [J].
Abernathy, SM ;
Miller, JC ;
Lohr, LL ;
Sharp, RR .
JOURNAL OF CHEMICAL PHYSICS, 1998, 109 (10) :4035-4046
[2]   Spin dynamics calculations of electron and nuclear spin relaxation times in paramagnetic solutions [J].
Abernathy, SM ;
Sharp, RR .
JOURNAL OF CHEMICAL PHYSICS, 1997, 106 (22) :9032-9043
[3]   Role of zero-field splitting interactions in the NMR paramagnetic relaxation enhancements produced by Ni(II)(acac)(2)(H2O)(2) [J].
Abernathy, SM ;
Sharp, RR .
JOURNAL OF PHYSICAL CHEMISTRY A, 1997, 101 (20) :3692-3698
[4]   GD-DTPA-CASCADE-POLYMER - POTENTIAL BLOOD-POOL CONTRAST AGENT FOR MR-IMAGING [J].
ADAM, G ;
NEUERBURG, J ;
SPUNTRUP, E ;
MUHLER, A ;
SCHERER, K ;
GUNTHER, RW .
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1994, 4 (03) :462-466
[5]   PHOSPHONATE-MODIFIED GDDTPA COMPLEXES .1. NMRD STUDY OF THE SOLUTION BEHAVIOR OF NEW TISSUE-SPECIFIC CONTRAST AGENTS [J].
ADZAMLI, IK ;
BLAU, M .
MAGNETIC RESONANCE IN MEDICINE, 1991, 17 (01) :141-148
[6]   Synthesis, NMR, relaxometry and circularly polarised luminescence studies of macrocyclic monoamidetris(phosphinate) complexes bearing a remote chiral centre [J].
Aime, S ;
Botta, M ;
Dickins, RS ;
Maupin, CL ;
Parker, D ;
Riehl, JP ;
Williams, JAG .
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1998, (06) :881-892
[7]   Synthesis and NMR studies of three pyridine-containing triaza macrocyclic triacetate ligands and their complexes with lanthanide ions [J].
Aime, S ;
Botta, M ;
Crich, SG ;
Giovenzana, GB ;
Jommi, G ;
Pagliarin, R ;
Sisti, M .
INORGANIC CHEMISTRY, 1997, 36 (14) :2992-3000
[8]   A multinuclear NMR study on the structure and dynamics of lanthanide(III) complexes of the poly(amino carboxylate) EGTA(4-) in aqueous solution [J].
Aime, S ;
Barge, A ;
Borel, A ;
Botta, M ;
Chemerisov, S ;
Merbach, AE ;
Muller, U ;
Pubanz, D .
INORGANIC CHEMISTRY, 1997, 36 (22) :5104-5112
[9]   Non-ionic Ln(III) chelates as MRT contrast agents: Synthesis, characterisation and H-1 NMR relaxometric investigations of bis(benzylamide) diethylenetriaminepentaacetic acid Lu(III) and Gd(III) complexes [J].
Aime, S ;
Benetollo, F ;
Bombieri, G ;
Colla, S ;
Fasano, M ;
Paoletti, S .
INORGANICA CHIMICA ACTA, 1997, 254 (01) :63-70
[10]   Extent of hydration of octadentate lanthanide complexes incorporating phosphinate donors: Solution relaxometry and luminescence studies [J].
Aime, S ;
Botta, M ;
Parker, D ;
Williams, JAG .
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1996, (01) :17-23
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