Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

被引：247
作者：
Chen, JY [1 ]
Park, CS [1 ]
Tang, SJ [1 ]
机构：
[1] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Qureshey Res Lab 303, Dept Neurobiol & Behav, Irvine, CA 92697 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2006年 / 281卷 / 17期
关键词：
D O I：
10.1074/jbc.M511920200
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-D-aspartate receptor-dependent synaptic Wnt3a release, nuclear beta-catenin accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation. These findings suggest that Wnt signaling plays a critical role in regulating synaptic plasticity.
引用
收藏
页码：11910 / 11916
页数：7
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