Potential biomarkers for antidiastole of tuberculous and malignant pleural effusion by proteome analysis

被引：7
作者：
Shi, Jing [1 ]
Li, Pu [2 ]
Zhou, Lijin [2 ]
Qi, Suwen [3 ]
Wang, Bo [2 ]
Li, Dandan [2 ]
Duan, Liang [2 ]
Chen, Wei Xian [2 ]
Xia, Jirong [1 ]
Zou, Lin [1 ]
Yang, Shuangshuang [1 ]
机构：
[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, Chongqing 400016, Peoples R China
[2] Chongqing Med Univ, Affiliated Hosp 2, Dept Lab Med, Chongqing 400010, Peoples R China
[3] Shenzhen Univ, Natl Reg Key Technol Engn Lab Med Ultrasound, Guangdong Key Lab Biomed Measurements & Ultrasoun, Dept Biomed Engn,Sch Med, Shenzhen 518060, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 02期
基金：
美国国家科学基金会;
关键词：
cathepsin G; fibronectin; iTRAQTM; leukotriene-A4; hydrolase; lung cancer; malignant pleural effusion; potential biomarkers; quantitative proteomic analyze; tuberculosis; tuberculous pleural effusion; ADENOSINE-DEAMINASE; DIAGNOSTIC YIELD; CATHEPSIN-G; FIBRONECTIN; MANAGEMENT; EXPRESSION; SURVIVAL;
D O I：
10.2217/bmm-2018-0200
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: To investigate novel potential biomarkers for antidiastole of tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE). Materials & methods: iTRAQTM-coupled LC-MS/MS were applied to analyze the proteome of TPE and MPE samples. The candidate proteins were verified by enzyme-linked immunosorbent assay. Results: A total of 432 differential proteins were identified. Enzyme-linked immunosorbent assay revealed significantly higher levels of fibronectin (FN) and cathepsin G (CTSG) in MPE than in TPE, but lower levels of leukotriene-A4 hydrolase (LTA4H). The receiver operator characteristic values were 0.285 for FN, 0.64 for LTA4H, 0.337 for CTSG and 0.793 for a combination of these candidate markers. Conclusion: FN, LTA4H and CTSG were identified as potential biomarkers to differentiate TPE from MPE and their combination exhibited higher diagnostic capacity.
引用
收藏
页码：123 / 133
页数：11
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