Total Synthesis of (+)-Linoxepin by Utilizing the Catellani Reaction

被引：114

作者：

Weinstabl, Harald ^{[1
]}

Suhartono, Marcel ^{[1
]}

Qureshi, Zafar ^{[1
]}

Lautens, Mark ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Labs, Toronto, ON M5S 3H6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 20期

基金：

奥地利科学基金会;

关键词：

CH functionalization; Catellani reaction; domino reactions; lignans; total synthesis; DOMINO REACTIONS; RING-SYSTEM; LIGNANS; ELIMINATION; MECHANISM; ARYLATION; ALKENES;

D O I：

10.1002/anie.201302327

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Molecular intelligence: The structurally novel lignan (+)-linoxepin is synthesized in an eight-step sequence. The enantioselective synthesis features the palladium-catalyzed Catellani reaction as the key step. In this highly convergent multicomponent reaction, two new carbon-carbon bonds are formed, one of which results from a C-H bond functionalization. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5305 / 5308

页数：4

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