CATERPILLERs, pyrin and hereditary immunological disorders

被引：242
作者：
Ting, JPY [1 ]
Kastner, DL
Hoffman, HM
机构：
[1] Univ N Carolina, Dept Immunol Microbiol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[2] NIH, Genet & Gen Branch NIAMS, Bethesda, MD 20892 USA
[3] Univ Calif San Diego, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 03期
关键词：
D O I：
10.1038/nri1788
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This family has gained rapid prominence because of its demonstrated and anticipated roles in immunity, cell death and growth, and diseases. CATERPILLER proteins are structurally similar to a subgroup of plant-disease-resistance (R) proteins and to the apoptotic protease activating factor 1 (APAF1). They provide positive and negative signals for the control of immune and inflammatory responses, and might represent intracellular sensors of pathogen products. Most importantly, they are genetically linked to several human immunological disorders.
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页码：183 / 195
页数：13
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