Obesity: A Transgenerational Problem Linked to Nutrition during Pregnancy

被引：45

作者：

Frias, Antonio E. ^{[1
]}

Grove, Kevin L. ^{[2
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97239 USA

[2] OHSU, Oregon Natl Primate Ctr, Div Neurosci, Beaverton, OR USA

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2012年 / 30卷 / 06期

基金：

美国国家卫生研究院;

关键词：

obesity; pregnancy; high fat diet; placenta; programming; HIGH-FAT DIET; BODY-MASS INDEX; MATERNAL OBESITY; METABOLIC SYNDROME; ADIPOSE-TISSUE; FETAL-DEATH; IN-UTERO; PREPREGNANCY OBESITY; INSULIN-RESISTANCE; DIABETES-MELLITUS;

D O I：

10.1055/s-0032-1328875

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The increased obstetric risks of maternal obesity have been well described. These include increased risks of gestational diabetes mellitus, preeclampsia, stillbirth, and cesarean delivery. The fetal/neonatal consequences of prenatal maternal obesity have received less attention. In addition to an increased risk of stillbirth, the fetal/neonatal consequences include increased adiposity and a metabolic status that increases the lifetime risk of obesity and diabetes. This review focuses on the clinical obstetric consequences of maternal obesity and highlights recent mechanistic insights on fetal programming as well as evidence suggesting that prenatal care provides a unique opportunity to ameliorate these risks and decrease the cycle of childhood obesity.

引用

页码：472 / 478

页数：7

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