A Novel Protocol for the Cu-Catalyzed Sonogashira Coupling Reaction between Aryl Halides and Terminal Alkynes using trans-1,2-Diaminocyclohexane Ligand

被引：19

作者：

Asha, Sujatha ^{[1
,2
]}

Thomas, Anns Maria ^{[1
,3
]}

Ujwaldev, Sankuviruthiyil M. ^{[1
]}

Anilkumar, Gopinathan ^{[1
,4
]}

机构：

[1] Mahatma Gandhi Univ, Sch Chem Sci, PD Hills PO, Kottayam 686560, Kerala, India

[2] Sree Vidyadhiraja NSS Coll, Vazhoor PO, Kottayam 686505, Kerala, India

[3] Nirmala Coll, Muvattupuzha PO, Ernakulam 686661, India

[4] Mahatma Gandhi Univ, Adv Mol Mat Res Ctr AMMRC, PD Hills PO, Kottayam 686560, Kerala, India

来源：

CHEMISTRYSELECT | 2016年 / 1卷 / 13期

关键词：

catalysis; copper; C-C coupling; Sonogashira coupling; 1,2-trans-diaminocyclohexane; PALLADIUM-FREE; DERIVATIVES; EFFICIENT; IODIDES; BENZOFURAN; ANALOGS; DABCO;

D O I：

10.1002/slct.201600894

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient Sonogashira coupling reaction has been reported using cost effective and easily accessible CuI/trans-1,2-diaminocyclohexane catalytic system. The newly developed method can be successfully employed for the coupling between aryl and heteroaryl halides with terminal acetylenes. Furthermore this methodology can be extended for the one pot synthesis of biologically active benzofuran derivatives.

引用

页码：3938 / 3941

页数：4

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