Immunotherapy combinations for the treatment of patients with solid tumors

被引：10

作者：

Virginia Bluthgen, Maria ^{[1
]}

Bast, Neus ^{[2
]}

Recondo, Gonzalo ^{[3
]}

机构：

[1] Hosp Aleman Buenos Aires, Med Oncol, RA-1118 Buenos Aires, DF, Argentina

[2] Hosp Clin Barcelona, Med Oncol, Barcelona 08036, Spain

[3] Ctr Educ Med & Invest Clin CEMIC, Med Oncol, RA-1431 Buenos Aires, DF, Argentina

来源：

FUTURE ONCOLOGY | 2020年 / 16卷 / 23期

关键词：

anti-angiogenesis; chemotherapy; combination; immunotherapy; kinase inhibitor; CELL LUNG-CANCER; NIVOLUMAB PLUS IPILIMUMAB; NEGATIVE BREAST-CANCER; OPEN-LABEL; ADVANCED MELANOMA; MICROSATELLITE INSTABILITY; PHASE-III; CHEMOTHERAPY CHEMO; MUTATIONAL BURDEN; PEMBROLIZUMAB;

D O I：

10.2217/fon-2020-0303

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibitors directed against CTLA-4, PD-1 and PD-L1 have transformed the treatment of patients with cancer. Immunotherapy regimens have evolved from a single agent approach to the combination of immune checkpoint inhibitors like anti CTLA-4 and PD-1, immune checkpoint blockade combined with chemotherapy, anti-angiogenic agents and kinase inhibitors. These synergistic combinations were developed to heighten the potency and duration of immune responses against cancer cells. Hence, immunotherapy combinations have shaped the landscape of therapeutic options against a wide range of cancer types, and are current standard treatment regimens worldwide. In this review, we describe the clinical evidence supporting the use of immunotherapy combination regimens for the treatment of patients with solid tumors.

引用

页码：1715 / 1736

页数：22

共 143 条

[1] Outcomes to first-line pembrolizumab in patients with non-small-cell lung cancer and very high PD-L1 expression [J].

Aguilar, E. J. ;

Ricciuti, B. ;

Gainor, J. F. ;

Kehl, K. L. ;

Kravets, S. ;

Dahlberg, S. ;

Nishino, M. ;

Sholl, L. M. ;

Adeni, A. ;

Subegdjo, S. ;

Khosrowjerdi, S. ;

Peterson, R. M. ;

Digumarthy, S. ;

Liu, C. ;

Sauter, J. ;

Rizvi, H. ;

Arbour, K. C. ;

Carter, B. W. ;

Heymach, J. V. ;

Altan, M. ;

Hellmann, M. D. ;

Awad, M. M. .

ANNALS OF ONCOLOGY, 2019, 30 (10) :1653-1659

[2] Genomic Classification of Cutaneous Melanoma [J].

Akbani, Rehan ;

Akdemir, Kadir C. ;

Aksoy, B. Arman ;

Albert, Monique ;

Ally, Adrian ;

Amin, Samirkumar B. ;

Arachchi, Harindra ;

Arora, Arshi ;

Auman, J. Todd ;

Ayala, Brenda ;

Baboud, Julien ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barnabas, Nandita ;

Bartlett, John ;

Bartlett, Pam ;

Bastian, Boris C. ;

Baylin, Stephen B. ;

Behera, Madhusmita ;

Belyaev, Dmitry ;

Benz, Christopher ;

Bernard, Brady ;

Beroukhim, Rameen ;

Bir, Natalie ;

Black, Aaron D. ;

Bodenheimer, Tom ;

Boice, Lori ;

Boland, Genevieve M. ;

Bono, Riccardo ;

Bootwalla, Moiz S. ;

Bosenberg, Marcus ;

Bowen, Jay ;

Bowlby, Reanne ;

Bristow, Christopher A. ;

Brockway-Lunardi, Laura ;

Brooks, Denise ;

Brzezinski, Jakub ;

Bshara, Wiam ;

Buda, Elizabeth ;

Burns, William R. ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Calderone, Tiffany ;

Cappellini, Giancarlo Antonini ;

Carter, Candace ;

Carter, Scott L. ;

Cherney, Lynn ;

Cherniack, Andrew D. ;

Chevalier, Aaron ;

Chin, Lynda .

CELL, 2015, 161 (07) :1681-1696

[3] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[4]

[Anonymous], 2019, J CLIN ONCOL S

[5]

[Anonymous], 2018, J THORAC ONCOL

[6]

[Anonymous], 2019, J CLIN ONCOL S

[7] Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma [J].

Ascierto, Paolo Antonio ;

Ferrucci, Pier Francesco ;

Fisher, Rosalie ;

Del Vecchio, Michele ;

Atkinson, Victoria ;

Schmidt, Henrik ;

Schachter, Jacob ;

Queirolo, Paola ;

Long, Georgina V. ;

Di Giacomo, Anna Maria ;

Svane, Inge Marie ;

Lotem, Michal ;

Bar-Sela, Gil ;

Couture, Felix ;

Mookerjee, Bijoyesh ;

Ghori, Razi ;

Ibrahim, Nageatte ;

Moreno, Blanca Homet ;

Ribas, Antoni .

NATURE MEDICINE, 2019, 25 (06) :941-+

[8] Combination immunotherapy strategies in advanced non-small cell lung cancer (NSCLC): Does biological rationale meet clinical needs? [J].

Attili, Ilaria ;

Passaro, Antonio ;

Pavan, Alberto ;

Conte, PierFranco ;

De Marinis, Filippo ;

Bonanno, Laura .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2017, 119 :30-39

[9] Landscape of Microsatellite Instability Across 39 Cancer Types [J].

Bonneville, Russell ;

Krook, Melanie A. ;

Kautto, Esko A. ;

Miya, Jharna ;

Wing, Michele R. ;

Chen, Hui-Zi ;

Reeser, Julie W. ;

Yu, Lianbo ;

Roychowdhury, Sameek .

JCO PRECISION ONCOLOGY, 2017, 1 :1-15

[10] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

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