Chemokines: more than just road signs

被引：111
作者：
Bachmann, MF
Kopf, M
Marsland, BJ
机构：
[1] Cytos Biotechnol AG, CH-8952 Zurich, Switzerland
[2] ETH, Dept Environm Sci, CH-8092 Zurich, Switzerland
来源：
NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 02期
关键词：
D O I：
10.1038/nri1776
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chemokines have long been known to orchestrate dendritic-cell migration in the body. However, recent evidence has shown that chemokines not only direct the trafficking of dendritic cells but also can regulate their maturation status. Here, we propose that this dual function of chemokines ensures that T cells and dendritic cells meet in T-cell regions of lymphoid organs and that antigen is presented in an immunologically optimal context for T-cell priming.
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页码：159 / 164
页数：6
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