Interleukin-6 in Sera of Mice Inoculated with Group A Streptococcus and Cultural Supernatants

被引：0
作者：
Danilova, T. A. [1 ]
Danilina, G. A. [1 ]
Adzhieva, A. A. [1 ]
Minko, A. G. [1 ]
Zhukhovitskii, V. G. [1 ]
机构：
[1] Minist Healthcare Russian Federat, NF Gamaleya Fed Res Ctr Epidemiol & Microbiol, Lab Microbiol Latent Infect, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 06期
关键词：
interleukin-6; cytokines; group A streptococcus; immune response; NECROSIS-FACTOR-ALPHA; INFECTIONS; CYTOKINES; SEVERITY; PYOGENES;
D O I：
10.1007/s10517-016-3513-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Dynamics of IL-6 level was studied in blood serum of CBA mice receiving intraperitoneal injections of killed and live culture of group A Streptococcus and its supernatants. It was found that administration of killed culture was followed by a significant rise in IL-6 level (by 4.7 times in 1 h and by 9.3 times in 5 h in comparison with the control). By 24 h, cytokine content was below the control. The highest levels of IL-6 were found after treatment with supernatants of Streptococcus cultures (by 10.5 times in 1 h and by 14.9 times in 5 h, in comparison with the control). Administration of live culture was accompanied by an increase in IL-6 concentration by 3.2 times in 3 h. In this experimental series, the maximum level of IL-6 was found in 48 h (by 5.2 times), and then it gradually decreased below the control. Different dynamics of changes in IL-6 level after administration of killed and live cultures of group A Streptococcus may suggests that they activate different signal pathways.
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收藏
页码：797 / 800
页数：4
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