Combinatorial thinking in chemistry and biology

被引：31

作者：

Ellman, J

Stoddard, B

Wells, J

机构：

[1] FRED HUTCHINSON CANC RES CTR,SEATTLE,WA 98104

[2] GENENTECH INC,DEPT PROT ENGN,S SAN FRANCISCO,CA 94080

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 07期

关键词：

D O I：

10.1073/pnas.94.7.2779

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：2779 / 2782

页数：4

共 13 条

[1] IN-VITRO SELECTION FROM PROTEIN AND PEPTIDE LIBRARIES [J].

CLACKSON, T ;

WELLS, JA .

TRENDS IN BIOTECHNOLOGY, 1994, 12 (05) :173-184

[2] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .1. BACKGROUND AND PEPTIDE COMBINATORIAL LIBRARIES [J].

GALLOP, MA ;

BARRETT, RW ;

DOWER, WJ ;

FODOR, SPA ;

GORDON, EM .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (09) :1233-1251

[3]

GORDON EM, 1994, J MED CHEM, V37, P1386

[4] COMBINATORIAL LIBRARIES - FINDING THE NEEDLE IN THE HAYSTACK [J].

HOUGHTEN, RA .

CURRENT BIOLOGY, 1994, 4 (06) :564-567

[5] EXPEDIENT METHOD FOR THE SOLID-PHASE SYNTHESIS OF ASPARTIC-ACID PROTEASE INHIBITORS DIRECTED TOWARD THE GENERATION OF LIBRARIES [J].

KICK, EK ;

ELLMAN, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (09) :1427-1430

[6] MEASURING DIVERSITY - EXPERIMENTAL-DESIGN OF COMBINATORIAL LIBRARIES FOR DRUG DISCOVERY [J].

MARTIN, EJ ;

BLANEY, JM ;

SIANI, MA ;

SPELLMEYER, DC ;

WONG, AK ;

MOOS, WH .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (09) :1431-1436

[7] Tackling turbulence with supercomputers [J].

Moin, P ;

Kim, J .

SCIENTIFIC AMERICAN, 1997, 276 (01) :62-68

[8]

Scott Jamie K., 1994, Current Opinion in Biotechnology, V5, P40, DOI 10.1016/S0958-1669(05)80068-0

[9] Chemistry - Combinatorial chemistry hits the drug market [J].

Service, RF .

SCIENCE, 1996, 272 (5266) :1266-1268

[10]

SMITH CP, 1991, CURR OPIN STRUC BIOL, V1, P668

← 1 2 →