Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter

被引：27
|
作者：
Shintani, Ryo [1 ]
Ito, Tomoaki [1 ]
Nagamoto, Midori [1 ]
Otomo, Haruka [1 ]
Hayashi, Tamio [1 ,2 ]
机构：
[1] Kyoto Univ, Dept Chem, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan
[2] ASTAR, Inst Mat Res & Engn, Singapore 117602, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 79期
关键词：
ALPHA CONVERTING-ENZYME; KETENE SILYL ACETAL; NUCLEOPHILIC-ATTACK; GAMMA-LACTAM; (PI-ALLYL)PALLADIUM COMPLEXES; PHOSPHORAMIDITE LIGAND; ENANTIOSELECTIVE CONSTRUCTION; STEREOSELECTIVE-SYNTHESIS; SELECTIVE INHIBITORS; CONJUGATE ADDITION;
D O I：
10.1039/c2cc35259a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary stereocenter at the 3-position has been achieved by the reaction of gamma-methylidene-delta-valerolactones with alkyl isocyanates. High enantioselectivity has been realized by employing a newly synthesized chiral phosphoramidite ligand.
引用
收藏
页码：9936 / 9938
页数：3
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