Convenient copper-mediated Chan-Lam coupling of 2-aminopyridine: facile synthesis of N-arylpyridin-2-amines

被引：23

作者：

Chen, Jianbin ^{[1
]}

Natte, Kishore ^{[1
]}

Man, Nikki Y. T. ^{[2
]}

Stewart, Scott G. ^{[2
]}

Wu, Xiao-Feng ^{[1
]}

机构：

[1] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany

[2] Univ Western Australia, Sch Chem & Biochem, Crawley, WA 6009, Australia

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 33期

关键词：

Heterocycles; Chan-Lam coupling; Copper catalyst; Pyridine; Aryl boronic acid; CATALYZED N-ARYLATION; C-H BONDS; PYRIDINE-NUCLEOTIDES; DIRECTING GROUP; CUPRIC ACETATE; ACIDS; ACCESS; ANNULATION; EFFICIENT; SP(2);

D O I：

10.1016/j.tetlet.2015.06.092

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and practical process for the synthesis of N-arylpyridin-2-amine derivatives has been developed. Under the assistance of copper, the desired products were produced from commercially available 2-aminopyridine and aryl boronic acids in moderate to good yields with good functional group tolerance. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4843 / 4847

页数：5

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