The reaction of digitoxin and digoxin with cyanoacetic acid hydrazide: Synthesis of coumarin, thiazole, thiophene and pyridine derivatives with potential biological activities

被引：9

作者：

Doss, SH ^{[1
]}

Wardakhan, WW

Louca, NA

机构：

[1] Natl Res Ctr, Hormones Dept, Giza, Egypt

[2] Natl Org Drug Control & Res, Cairo, Egypt

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 05期

关键词：

digitoxin; digoxin; cyanoacetic acid hydrazide;

D O I：

10.1007/BF02975179

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reaction of either Digitoxin or Digoxin with cyanoacetic acid hydrazide gave the hydrazone derivatives 3a and 3b respectively. The reactivity of the latter products towards chemical reagents was studied to give heterocyclic derivatives with potential biological activities.

引用

页码：377 / 384

页数：8

共 20 条

[1]

ADUMCZYK M, 1996, J STEROIDS, V61, P562

[2]

ANTONELLO C, 1979, PARMACO ED SCI, V34, P139

[3] REACTION OF KETONES WITH CYANACETIC ACID HYDRAZIDE AND SULFUR [J].

GEWALD, K ;

HOFMANN, I .

JOURNAL FUR PRAKTISCHE CHEMIE, 1969, 311 (03) :402-&

[4] CYCLIZATIONS OF CYANOTHIOACETAMIDE IN THE PRESENCE OF SULFUR [J].

GEWALD, K ;

SCHINDLER, R .

JOURNAL FUR PRAKTISCHE CHEMIE, 1990, 332 (02) :223-228

[5] REACTION OF 2-THIOPHENAMINES WITH HYDRAZINE [J].

GEWALD, K ;

HAIN, U ;

GRUNER, M .

CHEMISCHE BERICHTE-RECUEIL, 1988, 121 (03) :573-575

[6]

GEWALD K, 1980, CHIMIA, V34, P101

[7]

GEWALD K, 1989, Patent No. 273441

[8] Digitalis-like compounds: Synthesis and biological evaluation of 3 beta-(aminoalkylthio) derivatives [J].

Gobbini, M ;

Benicchio, A ;

Padoani, G ;

Torri, M ;

Melloni, P .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (04) :469-472

[9]

KANTOCI D, 1997, POSITIVE INOTROPIC O, V127

[10]

MOHAREB RM, 1994, J CHEM RES-S, P126

← 1 2 →