Priming of T follicular helper cells by dendritic cells

被引：60
|
作者：
Ballesteros-Tato, Andre [1 ]
Randall, Troy D. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA
来源：
IMMUNOLOGY AND CELL BIOLOGY | 2014年 / 92卷 / 01期
关键词：
CD4(+) T cells; dendritic cells; T follicular helper; RESTRICTED ANTIGEN PRESENTATION; GERMINAL CENTER FORMATION; CENTER B-CELL; IN-VIVO; LYMPH-NODE; CUTTING EDGE; IL-2; PRODUCTION; REGULATORY-CELLS; BCL6; EXPRESSION; VIRAL-INFECTION;
D O I：
10.1038/icb.2013.62
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
T follicular helper cells (Tfh) are required to generate long-lived antibody responses, which confer long-term protection to pathogens following vaccination or infection. Despite significant advances in the field, however, little is known about the early steps that drive Tfh cell differentiation. In this review, we will discuss the mechanisms by which dendritic cells promote the initial commitment of activated CD4(+) T cells to the Tfh cell differentiation pathway.
引用
收藏
页码：22 / 27
页数：6
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