Effects of thyroid hormone withdrawal on natriuretic peptides during radioactive iodine therapy in female patients with differentiated thyroid cancer

被引：10
作者：
Stanciu, Adina Elena [1 ]
Hurduc, Anca Elena [2 ]
Stanciu, Marcel Marian [3 ]
机构：
[1] Inst Oncol Bucharest, Dept Carcinogenesis & Mol Biol, 252 Fundeni, Bucharest 022328, Romania
[2] Inst Oncol Bucharest, Dept Nucl Med, Bucharest, Romania
[3] Univ Politeh Bucharest, Dept Elect Engn Fac, Bucharest, Romania
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2016年 / 76卷 / 08期
关键词：
Amino acids; blood pressure; cardiac pumping; oncology; peptides and proteins; thyroid diagnostics and treatment; thyroid hormones; REMNANT ABLATION; HEART-FAILURE; DISEASE; BIOMARKERS; RISK; RECOMMENDATIONS; HYPOTHYROIDISM; RADIOIODINE; CARCINOMA; EVENTS;
D O I：
10.1080/00365513.2016.1230883
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: We aimed to investigate the effects of thyroid hormone withdrawal on N-terminal prohormone forms of atrial natriuretic peptide (NT-proANP) and brain natriuretic peptide (NT-proBNP) during radioiodine therapy in female patients with differentiated thyroid cancer (DTC).Methods: Serum concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), NT-proANP and NT-proBNP were measured in 51 female patients with DTC (48.74.2 years) at three time-points: day of radioiodine therapy (t1 - under acute hypothyroidism), 5 days after radioiodine (t2 - under acute hypothyroidism) and 3 months after radioiodine (t3 - under TSH suppression). Thirty healthy euthyroid women served as controls (42.85.6 years).Results: At t1/t2/t3, median NT-proANP was 5.2/1.7/487pmol/L vs. 297.7pmol/L in control group (p<0.001), median NT-proBNP was 50.1/36.5/79.5pmol/L vs. 64.5pmol/L (p<0.001) and median NT-proANP/NT-proBNP ratios was 0.20/0.18/4.81 vs. 4.14 (p<0.001). In acute hypothyroidism, FT3 levels were positively correlated with NT-proANP (r=0.38, p=0.005), NT-proANP/NT-proBNP ratios (r=0.47, p=0.001), heart rate (r=0.39, p=0.005), and negatively with mean arterial blood pressure (r=-0.58, p<0.001).Conclusions: Our results indicate that NT-proANP reflects more accurately direct thyroid hormone effects than NT-proBNP. Thyroid hormone-dependent hemodynamic effects seem to be overlapped on the direct stimulatory effect of thyroid hormones on NT-proANP secretion by cardiac myocytes.
引用
收藏
页码：626 / 631
页数：6
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