Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids

被引：10

作者：

Ge, Zhenyang ^{[1
]}

Duan, Zhijun ^{[1
]}

Yang, Hang ^{[1
]}

Zhang, Shengai ^{[1
]}

Zhang, Shuang ^{[1
]}

Wang, Lixia ^{[1
]}

Yang, Dong ^{[1
]}

Sun, Xiaoyu ^{[1
]}

Zhang, Zhifeng ^{[1
]}

Su, Liping ^{[1
]}

Zhu, Hong ^{[2
]}

Zhou, Dongdong ^{[2
]}

Liu, Bojia ^{[1
]}

Shi, Honggang ^{[1
]}

Yu, Jun ^{[1
]}

Yang, Hui ^{[1
]}

Chang, Qingyong ^{[3
]}

Zhang, Nina ^{[4
]}

Wu, Dongsheng ^{[5
]}

Chen, Jiande D. Z. ^{[6
]}

机构：

[1] Dalian Med Univ, Affiliated Hosp 1, Coll Integrat Med, Dept Gastroenterol 2,Neurogastroenterol and Motil, 222 Zhongshan Rd, Dalian 116011, Liaoning, Peoples R China

[2] Dalian Med Univ, Affiliated Hosp 1, Clin Lab, 222 Zhongshan Rd, Dalian 116011, Liaoning, Peoples R China

[3] Dalian Univ, Affiliated Zhongshan Hosp, Dept Neurosurg 2, 6 Jiefang St, Dalian 116001, Liaoning, Peoples R China

[4] Nanjing Drum Tower Hosp, Dept Gastroenterol, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China

[5] Queen Mary Univ London, Sch Engn & Mat Sci, London E1 4NS, England

[6] Johns Hopkins Ctr Neurogastroenterol, Div Gastroenterol & Hepatol, Baltimore, MD 21224 USA

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2018年 / 2018卷

关键词：

VASOACTIVE-INTESTINAL-PEPTIDE; IRRITABLE-BOWEL-SYNDROME; CARBON-INDUCED CONSTIPATION; FUNCTIONAL CONSTIPATION; NERVE-STIMULATION; COLONIC TRANSIT; PLASMA-LEVELS; SUBSTANCE-P; SEROTONIN; ELECTROACUPUNCTURE;

D O I：

10.1155/2018/2086163

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

This study aims to investigate the role of transcutaneous neuromodulation (TN) on the regulation of gastrointestinal hormones and bile acids in patients with functional constipation (FC). Twenty FC patients were treated with TN for four weeks. The effects of TN on symptoms were evaluated by questionnaires. Plasma levels of serotonin (5-HT), motilin, somatostatin, and vasoactive intestinal peptide (VIP) were measured by ELISA and 12 individual bile acids assayed by liquid chromatography tandem mass spectrometry. Results were as follows. (1) TN treatment increased the frequency of spontaneous bowel movement, improved the Bristol Stool Score, and reduced Patient Assessment of Constipation Symptom score and Patient Assessment of Constipation Quality of Life score. (2) FC patients showed decreased plasma levels of 5-HT, motilin, and VIP and an increased plasma level of somatostatin (P < 0.05). Four-week TN treatment increased plasma levels of 5-HT and motilin and decreased the plasma level of somatostatin in the FC patients (P < 0.05). (3) Taurocholic deoxycholate, taurocholic acid, and taurocholic lithocholic acid were increased in the FC patients (P < 0.005) but reduced by TN treatment (P < 0.05). This study has suggested that the therapy may improve the symptoms of FC by alleviating the disorders of gastrointestinal hormones and bile acids.

引用

页数：12

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