MICROWAVE ASSISTED ONE POT SYNTHESIS OF SOME PYRAZOLE DERIVATIVES AS A SAFER ANTI-INFLAMMATORY AND ANALGESIC AGENTS

被引：0

作者：

Alam, Mohammad Mumtaz ^{[1
]}

Marella, Akranth ^{[1
]}

Akhtar, Mymoona ^{[1
]}

Husain, Asif ^{[1
]}

Yar, Mohammad Shahar ^{[1
]}

Shaquiquzzaman, Mohammad ^{[1
]}

Tanwar, Om Prakash ^{[1
]}

Saha, Rikta ^{[1
]}

Khanna, Suruchi ^{[2
]}

Shafi, Syed ^{[3
]}

机构：

[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, Drug Design & Med Chem Lab, New Delhi 110062, India

[2] Jamia Hamdard, Fac Pharm, Dept Pharmacol, New Delhi 110062, India

[3] Jamia Hamdard, Fac Sci, Dept Chem, New Delhi 110062, India

来源：

ACTA POLONIAE PHARMACEUTICA | 2013年 / 70卷 / 03期

关键词：

pyrazoloquinolines; green chemistry; microwave; anti-inflammatory; analgesic; SUBSTITUTED QUINOLINES; IN-VITRO; ANALOGS; DRUGS; ANTIMALARIAL; SERIES; ASSAY; UREA;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of pyrazolo[3,4-b]quinolines have been synthesized using one-pot water mediated synthetic route under microwave irradiation involving the condensation of 2-chloroquinoline-3-carbaldehydes with semicarbazide or 2,4-dinitrophenyl hydrazine. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. The pharmacological evaluation showed that the compounds are good at inhibiting edema induced by carrageenan and also showed prominent analgesic activity with lesser GI toxicity as indicated by severity index and LPO values.

引用

页码：435 / 441

页数：7

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