MICROWAVE ASSISTED ONE POT SYNTHESIS OF SOME PYRAZOLE DERIVATIVES AS A SAFER ANTI-INFLAMMATORY AND ANALGESIC AGENTS

被引：0

作者：

Alam, Mohammad Mumtaz ^{[1
]}

Marella, Akranth ^{[1
]}

Akhtar, Mymoona ^{[1
]}

Husain, Asif ^{[1
]}

Yar, Mohammad Shahar ^{[1
]}

Shaquiquzzaman, Mohammad ^{[1
]}

Tanwar, Om Prakash ^{[1
]}

Saha, Rikta ^{[1
]}

Khanna, Suruchi ^{[2
]}

Shafi, Syed ^{[3
]}

机构：

[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, Drug Design & Med Chem Lab, New Delhi 110062, India

[2] Jamia Hamdard, Fac Pharm, Dept Pharmacol, New Delhi 110062, India

[3] Jamia Hamdard, Fac Sci, Dept Chem, New Delhi 110062, India

来源：

ACTA POLONIAE PHARMACEUTICA | 2013年 / 70卷 / 03期

关键词：

pyrazoloquinolines; green chemistry; microwave; anti-inflammatory; analgesic; SUBSTITUTED QUINOLINES; IN-VITRO; ANALOGS; DRUGS; ANTIMALARIAL; SERIES; ASSAY; UREA;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of pyrazolo[3,4-b]quinolines have been synthesized using one-pot water mediated synthetic route under microwave irradiation involving the condensation of 2-chloroquinoline-3-carbaldehydes with semicarbazide or 2,4-dinitrophenyl hydrazine. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. The pharmacological evaluation showed that the compounds are good at inhibiting edema induced by carrageenan and also showed prominent analgesic activity with lesser GI toxicity as indicated by severity index and LPO values.

引用

页码：435 / 441

页数：7

共 31 条

[1] Biarylether amide quinolines as liver X receptor agonists
Bernotas, Ronald C.
Singhaus, Robert R.
Kaufman, David H.
Ullrich, John
Fletcher, Horace, III
Quinet, Elaine
Nambi, Ponnal
Unwalla, Rayomand
Wilhelmsson, Anna
Goos-Nilsson, Annika
Farnegardh, Mathias
Wrobel, Jay
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (04) : 1663 - 1670
[2] Synthesis and HMG CoA reductase inhibition of 4-thiophenyl quinolines as potential hypocholesterolemic agents
Cai, Zhengyan
Zhou, Weicheng
Sun, Lixin
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (24) : 7809 - 7829
[3] Catherine M. O., 2002, AM FAM PHYSICIAN, V65, P455
[4] Synthesis and anti-inflammatory evaluation of 9-phenoxyacridine and 4-phenoxyfuro[2,3-b]quinofine derivatives.: Part 2
Chen, YL
Chen, IL
Lu, CM
Tzeng, CC
Tsao, LT
Wang, JP
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (18) : 3921 - 3927
[5] New amine and urea analogs of ferrochloroquine: synthesis, antimalarial activity in vitro and electrochemical studies
Chibale, K
Moss, JR
Blackie, M
van Schalkwyk, D
Smith, PJ
[J]. TETRAHEDRON LETTERS, 2000, 41 (32) : 6231 - 6235
[6] ROLE OF DIRECT TISSUE CONTACT IN THE PRODUCTION OF GASTRO-INTESTINAL ULCERS BY ANTI-INFLAMMATORY DRUGS IN RATS
CIOLI, V
ROSSI, V
PUTZOLU, S
BARCELLONA, PS
CORRADINO, C
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1979, 50 (02) : 283 - 289
[7] Microwave-assisted synthesis in water as solvent
Dallinger, Doris
Kappe, C. Oliver
[J]. CHEMICAL REVIEWS, 2007, 107 (06) : 2563 - 2591
[8] The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea:: Synthesis, cytostatic and antiviral activity evaluations
Dzimbeg, G.
Zorc, B.
Kralj, M.
Ester, K.
Pavelic, K.
Andrei, G.
Snoeck, R.
Balzarini, J.
De Clercq, E.
Mintas, M.
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (06) : 1180 - 1187
[9] New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines
El-Gazzar, A. B. A.
Hafez, H. N.
Nawwar, G. A. M.
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (04) : 1427 - 1436
[10] Faurun C., 1976, CHEM ABSTR, V84

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