Measurement of renal function in patients with chronic kidney disease

被引:55
作者
Sandilands, Euan A. [1 ]
Dhaun, Neeraj [2 ,3 ]
Dear, James W. [1 ,2 ]
Webb, David J. [2 ]
机构
[1] Royal Infirm Edinburgh NHS Trust, NPIS Edinburgh, Edinburgh EH16 4SA, Midlothian, Scotland
[2] Univ Edinburgh, Queens Med Res Inst, Univ British Heart Fdn Ctr Cardiovasc Sci, Clin Pharmacol Unit, Edinburgh, Midlothian, Scotland
[3] Royal Infirm Edinburgh NHS Trust, Dept Renal Med, Edinburgh EH16 4SA, Midlothian, Scotland
关键词
chronic kidney disease; glomerular filtration rate; renal dysfunction; GLOMERULAR-FILTRATION-RATE; SERUM CYSTATIN-C; GELATINASE-ASSOCIATED LIPOCALIN; PROTEIN-CREATININE RATIO; INJURY MOLECULE-1 KIM-1; ACID-BINDING PROTEIN; PLASMA-CLEARANCE; I-125; IOTHALAMATE; URINARY BIOMARKER; PROGNOSTIC VALUE;
D O I
10.1111/bcp.12198
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Chronic kidney disease affects millions of people worldwide and is associated with an increased morbidity and mortality as a result of kidney failure and cardiovascular disease. Accurate assessment of kidney function is important in the clinical setting as a screening tool and for monitoring disease progression and guiding prognosis. In clinical research, the development of new methods to measure kidney function accurately is important in the search for new therapeutic targets and the discovery of novel biomarkers to aid early identification of kidney injury. This review considers different methods for measuring kidney function and their contribution to the improvement of detection, monitoring and treatment of chronic kidney disease.
引用
收藏
页码:504 / 515
页数:12
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