A synthesis of biaryls via nickel(0)-catalyzed cross-coupling reaction of chloroarenes with phenylboronic acids

被引：156

作者：

Saito, S ^{[1
]}

Sakai, M ^{[1
]}

Miyaura, N ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC ENGN,DIV MOL CHEM,SAPPORO,HOKKAIDO 060,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 17期

关键词：

D O I：

10.1016/0040-4039(96)00482-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cross-coupling reaction of phenylboronic acid with chloroarenes to give biaryls was carried out in high yields at 80 degrees C in the presence of the nickel(0) catalyst and K3PO4 (3 equivs) in dioxane. The nickel(0) catalyst prepared in situ from NiCl2(dppf) (10 mol%) and four equivalents of BuLi was recognized to be most effective. The reaction can be applicable for a wide range of chloroarenes having an electron-withdrawing or an electron-donating group such as 4-CN-, 4-CHO, 2- or 4-CO(2)Me, 4-COMe, 4-NHAc, 3- or 4-Me, and 3- or 4-OMe, and 4-NH2. (C) 1996 Elsevier Science Ltd

引用

页码：2993 / 2996

页数：4

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