Arterial Tissue Regeneration for Pediatric Applications: Inspiration From Up-to-Date Tissue-Engineered Vascular Bypass Grafts

被引：10

作者：

Cittadella, Giorgio ^{[1
]}

de Mel, Achala ^{[1
]}

Dee, Ryan ^{[1
]}

De Coppi, Paolo ^{[2
,3
]}

Seifalian, Alexander M. ^{[1
,4
]}

机构：

[1] UCL, UCL Ctr Nanotechnol & Regenerat Med, London NW3 2PF, England

[2] UCL, Inst Child Hlth, London NW3 2PF, England

[3] UCL, Great Ormond St Hosp, London NW3 2PF, England

[4] Royal Free NHS Fdn Trust Hosp, London, England

来源：

ARTIFICIAL ORGANS | 2013年 / 37卷 / 05期

关键词：

Small diameter grafts; Tissue engineering; Autologous cells; Regenerative; IN-SITU ENDOTHELIALIZATION; HUMAN BLOOD-VESSEL; BONE-MARROW; NANOCOMPOSITE BIOMATERIAL; SMOOTH-MUSCLE; CELLS; AUTOGRAFTS; CONSTRUCTION; REPLACEMENT; SCAFFOLDS;

D O I：

10.1111/aor.12022

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The need for a valid replacement for autologous tissues in vascular surgery has led to the development of tissue-engineered vascular grafts (TEVGs). Currently, only three kinds of TEVG have been used in clinical trials: synthetic scaffold-based TEVGs, self-assembled grafts, and decellularized exogenous tissues. This review presents the current options in the construction of TEVG and the changes that have occurred in the design following the clinical experience while focusing on the potential for pediatric applications. The emerging trend in the field, which is also pertinent for pediatric applications, is a shift from the development of vascular analogues to implants composed of scaffolds with autologous cellular components. Designs of such implants are currently being fine-tuned so that a natural, functional tissue can gradually take over the role of scaffolds to stimulate the host's regenerative capacity and maintain the physiological homeostasis.

引用

页码：423 / 434

页数：12

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